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MT 6314 PCOL > Beta-Lactams Antibiotics Cephalosporins & Cephamycins > Flashcards

Beta-Lactams Antibiotics Cephalosporins & Cephamycins Flashcards

1
Q

Derivatives of 7-aminocephalosporanic acid. More stable to many bacterial B-lactamases

A

Cephalosporins & Cephamycins

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2
Q

Cephalosporins that are excreted in bile

A

Cefoperazone and Ceftriaxone

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3
Q

Cephalosporins major elimination are via

A

renal tubular excretion

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4
Q

First-Generation Cephalosporins

A

Cephalexin, Cefazolin, Cefadroxil, Cephalotin, Cephadrine, Cephapirin

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5
Q

Second-Generation Cephalosporins

A

Cefuroxime, Cefoxitin, Cefotetan, Cefamandole, Cefaclor

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6
Q

Third-Generation Cephalosporins

A

Ceftriaxone, Cefotaxime, Cefoperazone, Ceftazidime, Cefixime

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7
Q

Fourth-Generation Cephalosporins

A

Cefepime

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8
Q

_______ and ______ gen don’t enter CSF even if meninges are inflamed

A

1st and 2nd

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9
Q

Not active against MRSA
a. First Gen
b. Fourth Gen

A

a. First Gen

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10
Q

Drug of choice against gram (+) cocci
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

c. Both

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11
Q

Drug of choice against E. coli
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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12
Q

Drug of choice against K. pneumoniae
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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13
Q

Drug of choice to treat Surgical Prophylaxis
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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14
Q

Drug of choice to treat cellulitis
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

b. Cephalexin

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15
Q

Drug of choice to treat Soft Tissue abscess
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

b. Cephalexin

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16
Q

Drug of choice to treat Skin and Soft Tissue Infections
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

c. Both

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17
Q

Toxicity of Drug fever is associated with
a. Cefazolin
b. Cephalexin
c. Both
d. Neither

A

a. Cefazolin

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18
Q

The only 1st gen parenteral drug still in use

A

Cefazolin

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19
Q

Drug of choice against Pneumococcus
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

a. Cefuroxime

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20
Q

Drug of choice against H. influenzae
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

a. Cefuroxime

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21
Q

Drug of choice against Anaerobes
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

b. Cefotetan

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22
Q

Drug of choice against Serratia
a. Cefuroxime
b. Cefotetan
c. both
d. neither

A

b. Cefotetan

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23
Q

Resistant to Serratia
a. Cefotetan
b. Cefoxitin
c. Cefuroxime

A

c. Cefuroxime

24
Q

Drug of choice to treat commonly-acquired pneumonia
a. Cefuroxime
b. Cefoxitin
c. Cephalexin

A

a. Cefuroxime

25
Q

Drug of choice to treat Mixed Anaerobic Infections
a. Cefuroxime
b. Cefoxitin
c. Cephalexin

A

b. Cefoxitin

26
Q

Drug of choice to treat Pelvic Inflammatory Disease
a. Cefuroxime
b. Cefoxitin
c. Cephalexin

A

b. Cefoxitin

27
Q

Drug of choice to treat Peritonitis
a. Cefuroxime
b. Cefoxitin
c. Cephalexin

A

b. Cefoxitin

28
Q

Drug of choice to treat Diverticulitis
a. Cefuroxime
b. Cefoxitin
c. Cephalexin

A

b. Cefoxitin

29
Q

Most active cephalosporins against penicillin-resistant pneumococci (PRSP)

A

Ceftriaxone

30
Q

Cephalosporins that cannot penetrate the BBB

A

cefoperazone and cefixime

31
Q

Third-Generation Cephalosporins that the only agent w/ useful activity against P. aeruginosa

A

Ceftazidime

32
Q

Not for gonococcal urethritis and cervicitis
a. Cefotaxime
b. Ceftazidime
c. Cefixime

A

c. Cefixime

33
Q

Drug of choice to treat Pneumonia
a. Ceftriaxone
b. Cefotaxime
c. Both
d. Neither

A

a. Ceftriaxone

34
Q

Drug of choice to treat Osteomyelitis
a. Ceftriaxone
b. Cefotaxime
c. Both
d. Neither

A

a. Ceftriaxone

35
Q

Drug of choice to treat Empiric Therapy for Serious Infections
a. Ceftriaxone
b. Cefotaxime
c. Both
d. Neither

36
Q

Drug of choice to treat Acute Otitis Media
a. Ceftriaxone
b. Cefotaxime
c. Both
d. Neither

A

a. Ceftriaxone

37
Q

Drug of choice to treat Meningitis
a. Ceftriaxone
b. Cefotaxime
c. Both
d. Neither

38
Q

Drug of choice to treat Pyelonephritis
a. Ceftriaxone
b. Cefotaxime
c. Both
d. Neither

A

a. Ceftriaxone

39
Q

Drug against MRSA (Methicillin-Resistant Staphylococcus aureus)
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

b. Ceftaroline

40
Q

Drug against MSSA (Methicillin-Susceptible Staphylococcus aureus)
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

41
Q

Drug against Enterobacteriacaea
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

42
Q

Drug against Haemophilus
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

43
Q

Drug against Neisseria
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

44
Q

First drug approved for MRSA

A

Ceftaroline

45
Q

Drug of choice to treat complicated P. aeruginosa infections
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

46
Q

Drug against Febrile Neutropenia
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

47
Q

Drug against community-acquired pneumonia
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

b. Ceftaroline

48
Q

Drug that penetrates well to cerebrospinal fluid
a. Cefepime
b. Ceftaroline
c. both
d. neither

A

a. Cefepime

49
Q

More resistant to hydrolysis by chromosomal B- lactamase but hydrolyzed by ESBL

50
Q

carbapenemase- producing organisms
a. Ceftazidime- avibactam
b. Ceftolozane- tazobactam
c. both
d. neither

A

a. Ceftazidime- avibactam

51
Q

Bound by active iron transporters and pumped into the bacterial cell wall at high conc

A

Cefiderocol

52
Q

Resistant to P. aeruginosa
a. Ceftaroline
b. Ceftazidime
c. Cefiderocol

A

a. Ceftaroline

53
Q

Resistant to Organisms w/ metallo-B-lactamase
a. Ceftaroline
b. Ceftazidime
c. Cefiderocol

A

b. Ceftazidime

54
Q

Resistant to Gram (+) anaerobic organisms
a. Ceftaroline
b. Ceftazidime
c. Cefiderocol

A

c. Cefiderocol

MT 6314 PCOL (3 decks)

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