Beta blockers in the cardiovascular system Flashcards

1
Q

What are beta blockers and how do they work?

A

Beta blockers are G protein-coupled receptors that affect alpha and beta-adrenoreceptors. They primarily block beta-adrenoreceptors. Some beta blockers are non-selective and also antagonize alpha-adrenoreceptors. When activated by catecholamines like adrenaline, beta-adrenoreceptors stimulate adenylyl cyclase, converting ATP to cAMP, which leads to heart muscle contraction, smooth muscle relaxation, and glycogenolysis.

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2
Q

What are the different types of beta-adrenoreceptors and their effects?

A

Beta 1: Primarily affects the heart.
Beta 2: Mainly affects the lungs and can cause bronchoconstriction, which may worsen asthma.
Beta 3: Located in adipose cells.
Non-selective beta blockers: Can block both beta and alpha-1 receptors, leading to smooth muscle relaxation.

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3
Q

What are the common uses of beta blockers?

A

Beta blockers are used to treat hypertension, ischaemic heart disease, angina, cardiac arrhythmias, abnormal cardiac rhythms, heart failure, and symptoms of anxiety.

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4
Q

How do beta blockers help in managing hypertension?

A

Beta blockers reduce the secretion of renin and can cause vasodilation if they are also alpha-1 blockers. This leads to a reduction in heart rate and cardiac output, helping to lower blood pressure. However, beta blockers are not the first-line treatment for hypertension and are typically used as the 4th or 5th line of treatment.

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5
Q

How do beta blockers work in the treatment of ischaemic heart disease and angina?

A

Beta blockers reduce myocardial oxygen demand and improve coronary blood flow, leading to antiarrhythmic effects. They also reduce the activity of the renin-angiotensin-aldosterone system, which helps reduce cardiac remodeling and lower blood pressure. This has been shown to reduce mortality by 20-40% in patients with ischaemic heart disease when co-prescribed with anti-platelets, statins, and ACE inhibitors. Beta blockers are one of the two first-line options for treating angina.

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6
Q

What role do beta blockers play in heart failure?

A

Beta blockers have a similar mechanism of action in heart failure as in ischaemic heart disease, especially in terms of antiarrhythmic effects and reducing cardiac remodeling. When co-prescribed with ACE inhibitors and aldosterone antagonists, beta blockers reduce mortality by about 20% in heart failure patients.

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7
Q

How do beta blockers help manage arrhythmias?

A

Beta blockers slow down the heart rate, which is particularly helpful in preventing fast heart rates associated with arrhythmias like atrial fibrillation and flutter. They can also reduce the risk of dangerous electrical signals originating from the ventricles, which could lead to ventricular tachycardia or fibrillation.

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8
Q

What happens when beta-adrenoreceptors are activated by catecholamines like adrenaline?

A

When beta-adrenoreceptors are activated by catecholamines like adrenaline, they stimulate adenylyl cyclase, which converts ATP to cAMP. This leads to heart muscle contraction, smooth muscle relaxation, and glycogenolysis.

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9
Q

How do beta blockers affect beta-2 adrenoreceptors?

A

Beta blockers that affect beta-2 adrenoreceptors can lead to bronchoconstriction, which can worsen conditions like asthma.

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10
Q

What is the significance of non-selective beta blockers?

A

Non-selective beta blockers can block both beta-adrenoreceptors (Beta 1, Beta 2) and alpha-1 adrenoreceptors, causing a wider range of effects, including smooth muscle relaxation and potential impacts on the lungs and heart.

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11
Q

Why are beta blockers not typically the first-line treatment for hypertension?

A

Beta blockers are not usually the first-line treatment for hypertension because they are typically used as the 4th or 5th line of treatment. Other medications are preferred for initial treatment.

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12
Q

What effect do beta blockers have on the renin-angiotensin-aldosterone system?

A

Beta blockers reduce the activity of the renin-angiotensin-aldosterone system (RAAS), which helps lower blood pressure and reduce cardiac remodeling in conditions like heart failure and ischaemic heart disease.

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13
Q

What is the combined effect of beta blockers, ACE inhibitors, and statins in treating ischaemic heart disease?

A

The combined use of beta blockers, ACE inhibitors, and statins in treating ischaemic heart disease leads to reduced mortality by 20-40%. These medications work together to reduce blood pressure, improve coronary blood flow, and reduce cholesterol levels.

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14
Q

How do beta blockers reduce myocardial oxygen demand in ischaemic heart disease?

A

Beta blockers reduce myocardial oxygen demand by decreasing heart rate and reducing the force of contraction, leading to less strain on the heart and improved coronary blood flow.

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15
Q

How do beta blockers contribute to antiarrhythmic effects in ischaemic heart disease?

A

Beta blockers help to stabilize the electrical activity of the heart, reducing the likelihood of arrhythmias by decreasing heart rate and preventing abnormal electrical signals from causing dangerous rhythms.

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16
Q

What effect do beta blockers have on cardiac remodeling in heart failure?

A

Beta blockers help reduce cardiac remodeling in heart failure by decreasing the harmful effects of overactive sympathetic nervous system activity, which in turn helps preserve heart function and reduce mortality.

17
Q

In which two conditions are beta blockers considered first-line treatment options?

A

Beta blockers are considered one of the two first-line treatment options for treating angina and ischaemic heart disease.

18
Q

What is the main reason for prescribing beta blockers to patients with arrhythmias?

A

Beta blockers are prescribed to patients with arrhythmias primarily to slow down the heart rate and reduce the risk of dangerous arrhythmic events, such as atrial fibrillation, flutter, and ventricular tachycardia.

19
Q

How do beta blockers affect heart rate in arrhythmic conditions?

A

Beta blockers reduce the heart rate, which is particularly important in arrhythmic conditions, as it can prevent the heart from beating too quickly, which can lead to more severe arrhythmias.

20
Q

How do beta blockers help in the treatment of anxiety?

A

Beta blockers help reduce the physical symptoms of anxiety, such as rapid heart rate and trembling, by blocking the effects of adrenaline on beta-adrenoreceptors.