Beta Blockers Flashcards
Beta I effects and Beta II effects
Beta I: Constriction of vascular smooth muscle
Beta II: Constriction of bronchial smooth muscle and decrease release of glucose from liver
BB Random Fact - Specific Uses
- Atenolol does not have reduced CV outcomes in HTN tx
»> don’t use for HTN - Metoprolol short-acting can be used post MI but not succinate (long-acting)
- Propranolol can be used to treat pheochromocytoma (adrenal tumor)
- Acebutolol can be used for ventricular arrhythmias
- BB can be given for performance anxiety
BB used for Angina
nadolol, propanolol, atenolol, bisoprolol, metoprolol
BB used for HF
carvedilol, bisoprolol, metoprolol, nebivolol,
BB Cardiac Adverse Effects (6)
Bradycardia Hypotension Decreased exercise capacity AV Block Heart Failure Masking of Hypoglycemia
BB Non Cardiac Adverse Effects (11)
Fatigue Dizzy Weak NV Abd Pain Sexual Dysfunction Hyperglycemia Bronchospasm (asthmatic pts at higher risk) Raynauds at risk for exacerbation Hyper/Hypoglycemia Insomnia/Nightmares (effects with melatonin)
BB and COPD/Asthma
USE Cardioselective Blockers
- Metoprolol
- Betaxolol
- Bisoprolol
- Atenolol
- Nebivolol
DO NOT USE Non cardioselective Blockers
- Nadolol
- Propanolol
- Timolol
BB Contraindications
2nd or 3rd degree heart block
cardiogenic shock
bradycardia
BB and Heart Failure
NOT contraindicated
- but should be intiated in acute exacerbation
BB OTHER NOTES (4)
- Start within 24hrs of AMI admission
- Use with care in diabetic patients (both)
- Titrate to DC
- BB are substrates of CYP2D6
BB used for A Fib
nadolol, propanolol, atenolol, bisprolol, metoprolol