Beta Blockers Flashcards
1
Q
What are Adrenergic receptors?
A
GPCRs
Respond to Adrenaline and Noradrenaline
Drug targets for both cardiac and asthma drugs
2
Q
What are Adrenaline and Noradrenaline?
A
Catecholamines
Generally result in fight-or-flight response
3
Q
What are the different types of GPCRs?
A
α or β
Further classification: α1, α2, β1, β2, β3
4
Q
What is Isoprenaline?
A
β receptor agonist
5
Q
What is Dichloroisoprenaline?
A
β receptor partial agonist
Inhibits relaxation of smooth muscle
Cardiac action- has some stimulant activity
6
Q
What is Propranolol?
A
Non-selective β antagonist
(S) isomer 100x more active than (R) isomer
Controls tachycardia tremor associated with anxiety
Also used in migraine prophylaxis
