Benzo overdose

Question 1

Benzo toxidrome s/s

Answer 1

• cns dep
• drowsiness
• stable vital signs

Question 2

Benzo toxidrome

Answer 2

Sedative Hypnotic

Question 3

treatment for benzo overdose

Answer 3

monitoring, supportive care
*high therapeutic index, rare death

Question 4

benzo w/drawal s/s

Answer 4

• Severe sleep disturbance
• panic attacks
• palpitations
• seizures
• death

Question 5

flumazenil dose and pearls

Answer 5

• benzo overdose
• dose .2mg IV over 15 min
• ped .01 mg/kg IV
• onset: 1-2 min, variable dosing
• controversial use, induces w/drawal (can be lethal)

Question 6

when to use flumazenil

Answer 6

• procedure sedation
• unintentional pediatric exposure (non-benzo dep)
• heaptic encephalopathy, z drug overdose, ethanol intox

Question 7

polysub overdose
(Elimination, Antidote, Supportive care)

Answer 7

• Elimination: activated charcoal
• Antidotes : NAC
• Supportive care: benzo

Question 8

Benzo vs flumazenil

Answer 8

• benzo has protective effect, non-lethal toxicity, rare death use when benzo not reason for overdose
• flumazenil precipitates w/drawal + lethal seizures, doesn’t reverse resp dep