Benign Tumors + Fibrocystic Changes

Question 1

Fibrocystic changes

does it increase risk of breast cancer

Answer 1

not usually

Question 2

Apocrine metaplasia in fibrocystic changes

does it increase risk of breast cancer

Answer 2

no! even though it’s a metaplasia it’s alright

Question 3

Sclerosing adenosis
what is it and
does it increase risk of breast cancer

Answer 3

increased glands + sclerosis
*may be calcified
2x increased risk for cancer

Question 4

Ductal hyperplasia

does it increase risk of breast cancer

Answer 4

yes

2x higher risk

Question 5

Atypical hyperplasia

does it increase risk of breast cancer

Answer 5

yes

5x higher risk

Question 6

Defining characteristic of intraductal papilloma

Answer 6

covered w/ 2 epithelial layers

• luminal epithelium
• myoepithelium

Question 7

Intraductal papilloma presentation

Answer 7

bloody nipple discharge

Question 8

Defining characteristic of intraductal carcinoma

Answer 8

absence of myoepithelial layer

typically in post-menopausal woman

Question 9

Intraductal carcinoma

presentation

Answer 9

bloody nipple discharge in post-menopausal women

Question 10

Fibrocystic changes that increase risk of malignancy

risk applies to

Answer 10

both breasts
*even if risky fibrocystic change is found in one breast, there is a higher risk of malignancy in the contralateral breast as well

Question 11

Most common benign neoplasm of breast

Answer 11

fibroadenoma

Question 12

Fibroadenoma

increased risk of malignancy?

Answer 12

none

Question 13

Phyllodes tumor

wth

Answer 13

variation of fibroadenoma
overgrowth of fibrous component
leaf-like projections

Question 14

Leaf-like projections of fibrous tissue in breast tumor

Answer 14

phyllodes tumor

variation of fibroadenoma

Question 15

Can phyllodes be malignant

Answer 15

sometimes

esp b/c it’s seen in post-menopausal women