Benign Tumors and Fibrocystic changes Flashcards
What is the most common change in the premenopausal breast? What mediates it? How and where does it present?
Fibrocystic change which is the development of fibrosis and cysts in the breast. Thought to be hormone mediated. Presents as vague irregularity of the breast tissue. Usually in the upper outer quadrant.
What does fibrocystic change look like under the microscope? Is it benign or malignant?
Cysts have a blue-dome appearance on gross exam. Benign, but some changes are associated with an increased risk for invasive carcinoma to both breasts.
What is thebreast cancer risk profile for fibrosis, cysts and apocrine metaplasia?
No increased risk
What is thebreast cancer risk profile for ductal hyperplasia and sclerosing adenosis?
2X increased risk
What is thebreast cancer risk profile for atypical hyperplasia?
5X increased risk
How is intraductal papilloma characterized? How does it present? What other condition presents like this?
Characterized by fibrovascular projections lined by epithelial (luminal) and myoepithelial cells. Classically presents as bloody nipple discharge in a PREmenopausal woman. Papillary carcinoma also presents similarly.
How is papillary carcinoma characterized? What increases its risk and which patients does it target?
Characterized by fibrovascular projections lined by epithelial (luminal) cells WITHOUT myoepithelial cells.Risk increases with age, so most commonly seen in POSTmenopausal women.
How is papillary carcinoma characterized? What increases its risk and which patients does it target?
Characterized by fibrovascular projections lined by epithelial (luminal) cells WITHOUT myoepithelial cells.Risk increases with age, so most commonly seen in POSTmenopausal women.
Which population does a fibroadenoma target? How does it present? What is it sensitive to? When does it grow? Is it malignant? Does it increase the risk for carcinoma?
Most common benign neoplasm of the breast in premenopausal women. Estrogen sensitive. Grows during pregnancy. Painful during the menustral cycle. Presents as a well circumscribed, mobile marble-like mass.
What is a phyllodes tumor? What does it look like on biopsy? Which population is it seen in? Is it malignant?
Fobroadenoma-like tumor with overgrowth of the fibrous component. Characteristic leaf-like projections are seen on biopsy. Most commonly seen in POSTmenopausal women. Can be malignant in some cases.
