Benign Tumors and Fibrocystic Changes Flashcards

1
Q

What is the most common change in the premenopausal breast; thought to be hormone mediated

A

development of fibrosis and cysts in the breast (fibrocystic change)

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2
Q

Presents as vague irregularity of the breast tissue (‘lumpy breast’), usually in the upper outer quadrant

A

fibrocystic change

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3
Q

how do benign cysts associated with fibrocystic change appear on gross exam?

A

blue dome appearance

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4
Q

some fibrocystic changes are associated with an increased risk of invasive carcinoma in

A

both breasts

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5
Q

fibrocystic changes increase the risk for ductal hyperlasia and sclerosis adenosis

A

2 fold

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6
Q

fibrocystic changes increase the risk for atypical hyperplasia

A

5 fold

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7
Q

what do you call papillary growth, usually into a large duct, that is characterized by fibrovascular projections lined by epithelial (luminal) AND myoepithelial cells?

A

intraductal papilloma

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8
Q

bloody nipple discharge in a premenopausal woman is most likely

A

intraductal papilloma

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9
Q

bloody nipple discharge differential

A

intraductal papilloma

papillary carcinoma

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10
Q

histology of papillary carcinoma

A

fibrovascular projections lined by epithelial cells WITHOUT underlying myoepithelial cells

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11
Q

histology of intraductal papilloma

A

fibrovascular projections lined by epithelial AND myoepithelial cellls

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12
Q

risk of papillary carcinoma increases with

A

age, so it’s more common in postmenopausal women

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13
Q

what is the most common benign neoplasm of the breast?

A

Fibroadenoma

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14
Q

in what population is fibroadenoma usually seen?

A

premenopausal women

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15
Q

presentation of fibroadenoma

A

well-circumscribed, mobile, marble-like mass

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16
Q

what characteristic of fibroadenoma makes it grow during pregnancy and be painful during menstrual cycle?

A

estrogen sensitive

17
Q

fibroadenoma prognosis

A

benign, with no increased risk of carcinoma

18
Q

what do you call a fibroadenoma-like tumor with overgrowth of the fibrous component

A

phyllodes tumor

19
Q

phyllodes tumor on biopsy

A

leaf like projections

20
Q

phyllodes tumor is most commonly seen in what population

A

postmenopausal women

21
Q

phyllodes tumor prognosis

A

can be malignant in some cases