Benign Tumors and Fibrocystic Changes

Question 1

What is the most common change in the premenopausal breast; thought to be hormone mediated

Answer 1

development of fibrosis and cysts in the breast (fibrocystic change)

Question 2

Presents as vague irregularity of the breast tissue (‘lumpy breast’), usually in the upper outer quadrant

Answer 2

fibrocystic change

Question 3

how do benign cysts associated with fibrocystic change appear on gross exam?

Answer 3

blue dome appearance

Question 4

some fibrocystic changes are associated with an increased risk of invasive carcinoma in

Answer 4

both breasts

Question 5

fibrocystic changes increase the risk for ductal hyperlasia and sclerosis adenosis

Answer 5

2 fold

Question 6

fibrocystic changes increase the risk for atypical hyperplasia

Answer 6

5 fold

Question 7

what do you call papillary growth, usually into a large duct, that is characterized by fibrovascular projections lined by epithelial (luminal) AND myoepithelial cells?

Answer 7

intraductal papilloma

Question 8

bloody nipple discharge in a premenopausal woman is most likely

Answer 8

intraductal papilloma

Question 9

bloody nipple discharge differential

Answer 9

intraductal papilloma

papillary carcinoma

Question 10

histology of papillary carcinoma

Answer 10

fibrovascular projections lined by epithelial cells WITHOUT underlying myoepithelial cells

Question 11

histology of intraductal papilloma

Answer 11

fibrovascular projections lined by epithelial AND myoepithelial cellls

Question 12

risk of papillary carcinoma increases with

Answer 12

age, so it’s more common in postmenopausal women

Question 13

what is the most common benign neoplasm of the breast?

Answer 13

Fibroadenoma

Question 14

in what population is fibroadenoma usually seen?

Answer 14

premenopausal women

Question 15

presentation of fibroadenoma

Answer 15

well-circumscribed, mobile, marble-like mass

Question 16

what characteristic of fibroadenoma makes it grow during pregnancy and be painful during menstrual cycle?

Answer 16

estrogen sensitive

Question 17

fibroadenoma prognosis

Answer 17

benign, with no increased risk of carcinoma

Question 18

what do you call a fibroadenoma-like tumor with overgrowth of the fibrous component

Answer 18

phyllodes tumor

Question 19

phyllodes tumor on biopsy

Answer 19

leaf like projections

Question 20

phyllodes tumor is most commonly seen in what population

Answer 20

postmenopausal women

Question 21

phyllodes tumor prognosis

Answer 21

can be malignant in some cases