Benign/Reactive Lymphadenopathies

Question 1

Protein that sends anti-apoptotic signal to developing B-cells in lymph nodes

Answer 1

Bcl-2

Question 2

Immunostains used to detect B cells

Answer 2

1. CD20 –> germinal centers, mantle zones
2. CD10 –> germinal centers

Question 3

Immunostains used to detect T cells

Answer 3

CD5 and CD3 –> mostly found in paracortex

Question 4

Key feature of reactive lymph node

Answer 4

Germinal centers are of quite variable size and shape

Question 5

Features of lymph node involved in malignancy

Answer 5

1. Not tender
2. Matted or immobile texture on exam

Question 6

Histological appearance of infectious mononucleosis infected lymph nodes

Answer 6

1. Normal architecture appears wiped out at low power
2. Polymorphic cell population in paracortex

Question 7

Peripheral blood apearance of infectious mononucleosis

Answer 7

Look like monocytes but have round, large nuclei –> don’t look like cookie-cutter cells

Question 8

Histological appearance of lupus lymphadenitis

Answer 8

Necrosis

Question 9

Histological appearance of demratopathic lymphadenopathy

Answer 9

1. Handful of small germinal centers with prominent mantle zones
2. Group of large pale areas full of histiiocytes
3. Histiiocytes are full of melanin

Question 10

Hsitological appearance of HIV lymphadenopathy

Answer 10

1. No CD4+ T cells so germinal centers are absent with residual mantle zone
2. Cell-rich germinal centers replaced by histiiocytes