Benign: Cervix

Question 1

Endocervical tunnel clusters

Answer 1

Two patterns:

1. Type A > Dilated spaces, filled with mucin, scalloped gland outlines
2. Type B > Lobular groups of small acini or tubules lined by flat epithelium

No desmoplasia or deep invasion

Negative for p53 (usually only positive in neoplastic lesions of the endocervix; except for florid microglandular hyperplasia)

Benign, no treatment required

Question 2

Microglandular hyperplasia

Answer 2

Usually in reproductive-age women

Tightly packed glands that vary in size
Bland nuclei
Absent mitosis
Scant stroma, usually has inflammatory cells
Cystic dilatation

DDx: endocervical AIS, well-diff endometrioid endometrial adenocarcinoma