Behcet's disease

Question 1

Which populations are notoriously affected by Behcet’s disease?

Answer 1

Japanese, Middle eastern, and mediterranean

Question 2

Genetic association of Behcet’s disease:

Answer 2

strong a/w HLA-B51 (B for behcet’s and 5 is almost like S)

Question 3

Clinical features of Behcet’s disease:

Answer 3

• recurrent oral ulcerations (aphthous stomatitis=first and most common sign)
• recurrent genital ulceration
• Ocular lesions (conjunctivitis, iridocyclitis, retinal vasculitis→can lead to blindness)
• facial/acral papulopustules
• EN-like lesions on leg

Question 4

Number 1 cause of morbidity in Behcets disease:

Answer 4

Ocular symptoms

Question 5

What organs can be involved in Behcet’s and what is the clinical course?

Answer 5

Any organ, unpredictable course

Question 6

Histopath of Behcet’s disease:

Answer 6

neutrophilic infiltrate around vessels w/ leukocytoclastic vasculitis

Question 7

Treatment of Behcet’s disease:

Answer 7

colchicine, dapsone are the go to’s

• also thalidomide, MTX, TNFai, azathioprine
• treat oral ulcers with high potency TCS and topical antimicrobials
• also magic mouthwash for pain
• treat genital ulcers with low potency TCS and TCI’s
• MUST TREAT systemically because this can affect all organs