Beale

Question 0

Rivaroxiban

Answer 0

15 mg BID with food for first 21 days

Question 1

Apixaban

Answer 1

10 mg BID for 7 days

Then 5 mg BID

Question 2

Dabigatran

Answer 2

150 mg BID

Question 3

Lepirudin Bolus

Answer 3

0.2 - 0.4 mg/kg IV

Question 4

Lepirudin Maintenance

Answer 4

0.1 - 0.15 mg/kg/hour IV

Question 5

UFH for prophylaxis

Answer 5

5,000 units SC every 12 hours

Question 6

Apixiban for Prophylaxis

Answer 6

2.5 mg BID

Question 7

Enoxaparin for prophylaxis

Answer 7

40 mg SC daily

Question 8

Enoxaparin prophylaxis for patient having knee replacement surgery

Answer 8

30 mg SC every 12 hours

Question 9

Dalteparin prophylaxis for low-moderate risk

Answer 9

2500 units SC Once daily

Question 10

Dalteparin prophylaxis for high risk

Answer 10

5000 units once daily

Question 11

Routine monitoring for efficacy is not required for most patient on LMWH except _______ (4 groups) _____ is measured

Answer 11

Pregnant woman
CrCl < 30 ml/min
Obese patient 
Newborn & Pediatric patient 
Anti-Xa levels

Question 12

Enoxaparin dosing

Answer 12

1 mg/kg SC every 12 hours or 1.5 kg/mg daily

Question 13

Tinzaparin dosing

Answer 13

175 anti-Xa IU/kg daily

Question 14

If possible, ____ should be used in place of a LMWH in patient with renal insufficiency

Answer 14

UFH

Question 15

Tinzaparin is contraindicated in patient with CRCl < _____

Answer 15

60 ml/min

Question 16

In patient with renal insufficiency, decease Enoxaparin to _____ when CrCl < 30 ml/min

Answer 16

1 mg/kg sc daily

Question 17

Anti-Xa levels should be obtained after the ___dose and drawn ____ hrs after the injection to measure peak activity

Answer 17

2nd or 3rd

4

Question 18

In heparin reversal, use __ mg of protamine for each _____ units of UFH administered

Answer 18

1

100

Question 19

LMWH has ____ half life, _____ bioavailability, and lower incidence of ____ and of major bleeding than UFH

Answer 19

Longer
Better
HIT

Question 20

Which has a more predictable dose response? UFH or LMWH

Answer 20

LMWH

Question 21

A therapeutic range for anti-Xa has not been established for _____

Answer 21

Fondaparinux

Question 22

There has been no report of ______ in patient with Fondaparinux , therefore routine monitoring of ______ is not necessary

Answer 22

HIT

Platelet

Question 23

Since _____ does not bind to fondaparinux, patient with uncontrolled bleeding on Fondaparinux should receive ______

Answer 23

Protamine

Recombinant factor VIIa

Question 24

What anticoagulants can patient with HIT use?

Answer 24

Lepirudin

Argatroban

Question 25

_____ has an indication for HIT, but that’s usually during percutaneous coronary intervention

Answer 25

Bivalirudin

Question 26

_____ for VTE takes place approximately 1 week after initial treatment began

Answer 26

Maintenance therapy

Question 27

Patient with stable INR should be monitored once every ____ weeks

Answer 27

12

Question 28

These anticoagulant are contraindicated in patient with CRCl of less than 30 ml/min

Answer 28

Fondaparinux

Rivaroxiban

Question 29

Tinzaparin is contraindicated in patient with CrCl of less than ______

Answer 29

60 ml/min

Question 30

Binge drinking ____ INR, chronic alcohol ingestion ____ INR

Answer 30

Increase

Decrease

Question 31

Diagnosis of HIT is based on 3 things:

Answer 31

Platelet count
Presence of thrombosis
Presence of heparin-dependent antibodies

Question 32

Name the component of 4T score for predicting the likelihood of HIT

Answer 32

Thrombocytopenia
Timing
Thrombosis
oTher cause of thrombocytopenia

Question 33

Argatroban dosing in patient with HIT

Answer 33

2 mcg/kg/min IV continuous infusion

Question 34

Desirudin dosing for prophylaxis

Answer 34

15 mg sc every 13 hours up to 12 days