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OQ Review > BCSC 8. External Disease and Cornea > Flashcards

BCSC 8. External Disease and Cornea Flashcards

1
Q

Cornea receives glucose from

A

Aqueous humor

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2
Q

Increased matrix metalloproteinase-9

A

DES

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3
Q

Initial treatment for neurotrophic ulcer

A

bandage contact lens

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4
Q

Shown to reduce postherpetic neuralgia (PHN)

A

Prior VZ vaccine reduces PHN by 66%

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5
Q

Broad activity against yeast and filamentous funghi

A

Topical amphotericin B 0.15%

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6
Q

Better for filamentous molds

A

Natamycin 5%

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7
Q

Treatment for repeated recurrence of HZ keratitis

A

maintenance dose of valacyclovir

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8
Q

Most common fungal corneal pathogen

A

Candida (yeast)

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9
Q

Radial perineuritis

A

Acanthamoebea keratitis

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10
Q

27 yo F s/p LASIK 6 wks ago noted to have infiltrate at interface with no improvement after 3 days of q1hr fluoroquinolone eyedrops. Next step

A

Lift flap; cx on blood, chocolate agar, Sabourad’s agar. Start Fortified vancoycin and gentamicin q1hr.

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11
Q

MC cause of late interface infections (after 2 weeks)

A

Slow-growing organisms - Candida or atypical mycobacteria. Require definitive identification of causative agent

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12
Q

Condition a/w keratinized epithelial cells (metaplastic epithelial change)

A

MUCOUS MEMBRANE PEMPHIGOID - associated conditions. SJS, TEN, GVHD (severe ocular surface dx)

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13
Q

Treatment for large corneal ulcer in nursing home patient

A

corneal scraping for culture and sensitivity testing, f/b fortified topical vancomycin and gentamicin

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14
Q

Tx for vision rehabilitation for severe ocular surface dx with SJS and TEN

A

OSTEO-ODONTO-KERATOPROSTHESIS and boston type II keratoprosthesis

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15
Q

Eosinophils in conjunctiva are less numerous and more often degranulated in ___ compared to ___.

A

Atopic keratoconjunctivitis c/t VKC

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16
Q

Percentage of patients with necrotizing scleritis that have detectable systemic disorder

A

66%

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17
Q

Percentage of patients with diffuse or nodular scleritis that have detectable systemic disorder

A

33%

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18
Q

central opacity of cornea with underlying ENDOTHELIAL DEFECT and IRIS ADHESIONS

A

Peters anomoly

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19
Q

Vertical ruptures in descemet membrane that can lead to corneal edema, permanent vertical striae in posterior cornea resulting in high astigmatism

A

Birth trauma injury

20
Q

Horizontal curvilinear breaks in the Descemet membrane associated with congenital glaucoma

A

Haab striae

21
Q

Opacities are accumulations of unesterified and esterified cholesterol and phospholipids

A

Schnyder corneal dystrophy

22
Q

X-linked recessive disorder of cornea

A

Hunter and Fabry

23
Q

Drug a/w cornea verticillata

A

Amiodarone

24
Q

Produces lysosomal deposits in basal corneal epithelium creating whorl-like pattern

A

Amiodarone (similar pattern found in Fabry’s disease)

25
Q

Inheritance of marfan syndrome

A

AD

26
Q

AD disorder a/w defect in fibrillin gene, lens subluxation, scleral thinning (blue) and CORNEAL FLATTENING

A

Marfan syndrome

27
Q

Corneal finding in Marfan

A

Corneal flattening

28
Q

Thinning of peripheral cornea that is quiet, noninflammatory, slowly progressive.

A

Terrien marginal degeneration

29
Q

Line of lipid deposits appears at leading edge of pannus

A

Terrien marginal degeneration

30
Q

Lucid interval occurs between limbus and peripheral edge of keratopathy

A

Calcific band keratopathy

31
Q

Fine, dustlike, basophilic deposits in bowman membrane

A

Band keratopathy

32
Q

Always treat traumatic hyphema with these medicines

A

TOPICAL CORTICOSTEROIDS and CYCLOPLEGIC drugs - reduce inflammation and put pupil at rest to reduce incidence of rebleeding. +/- oral corticosteroids if severe inflammation. Topical anti-hypertensives mainstay (beta-bloackers and alpha agonists)

33
Q

Clinical finding that best supports diagnosis of limbal stem cell failure

A

Absence of limbal palisades of Vogt, abnormal epithelium on cornea, vascularization

34
Q

Corneal epithelium is highly differentiated cell type that is entirely regenerated approximately

A

every 7 days

35
Q

Remove interrupted sutures s/p PK at this time interval

A

4 weeks

36
Q

Tx for Fuchs CED

A

Endothelial keratoplasty (DSEK or DMEK)

37
Q

POW3 s/p PKP p/w persistent epithelial defect

A

presume herpetic disease, trial of oral acyclovir 400 mg po QID. Giving topical corticosteroids is CONTRAINDICATED!!

38
Q

DDx enlarged Corneal Nerves

A 
MARKING "L" Cornea
M: MEN II B (med Ca thyroid, pheo, neuroma)
A: Acanthamoeba
R: Refsum's disease (phytanic acid/Riley Day)
K: Keratoconus
I: Icthyosis
N: Neurofibromatosis
G: Grafts (failed) Glaucoma (infantile)
L: Leprosy
39
Q

D/Dx Ring infiltrate

A 
the PATH to ring infiltrate
P: Pseudomonas
A: Acanthamoeba
T: Topical anesthetic abuse
H: Herpes simplex virus
40
Q

MPS does NOT heavily involve cornea

A

Sam the Hunter must see to shoot
S: Sanfilippo
H: Hunter

41
Q

MPS most heavily involves cornea

A

Hurler and Scheie’s

42
Q

Cloudy Corneas

A 
STUMPED
S: Sclerocornea
T: Tears in descemet's (infantile glaucoma, birth trauma)
U: Ulcers (HSV, bacterial, neutotrophic)
M: Metabolic (mucopolysaccaridosis)
P: Peter's anomaly
E: Endothelial dystrophies (CHED, PPMD, CHSD
D: Dermoid
43
Q

Direct penetration of intact epithelium

A 
"N & N Can Lyse Hole Skin"
Neisseria gonorrhea
N. meningidides
Corynebacterium diptheriae
Listeria
Hemophilis
Shigella
44
Q

Derived from neuroectoderm

A 
ROVINZ
R: RPE/Pig CB epi
O: Optic nerve/axons
V: Vit (all)
I: Iris sphincter/dilator
N: Neurosensory ret/nonpig CB epithelium
Z: Zonules
45
Q

Derived from surface ectoderm

A 
CCLLSZ
C: Cilia
C: Conj/Cornea epithelium
L: Lids/Lacrimal gland and drainage
L: Lens
S: Skin
Z: Zonules
46
Q

Derived from mesoderm

A 
MEETS
M: Mesoderm
E: EOM
E - Endotherlial blood vessels
T: Temporal sclera
S: Schlem's canal

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