Bcps Flashcards
Istradefylline
Nourianz
Adenosine antagonist
Parkinsons
Opicapone
Ongentys
Comp inhibitor for PD
Ozanimod
Zeposia
MS
Ponesimod
Ponvory
MS
Simponimod
Mayzent
MS
Cladrabine
Mavenclad
MS
Dalfampridine
Ampyra
MS- improves walking
Dextromethorphan/quinidine
Psedobulbar
(May be needed in MS)
Lumateperone
Caplyta
Atypical antipsych
Other clozapine issues
Seizures, thermoregulation issues, myocarditis/cardiomyopathy, anticholinergic, severe constipation
Aripiprazole and brexpiprazole funny ADRs
Compulsive behaviors (gambling)
Akathisia
Levomilnacipran vs milnacipran
Levo: depression
Milnacipran: FM
Both snri
Vortioxetine (trintellix)
SSRI
TCAs tertiary v secondary
Tertiary: amitriptyline, imipramine (more selective for seratonin)
Secondary: nortriptyline, desipramine ( more selective for NE and less anticholinergic )
MAOIs
Non-selective: isocatboxazid, phenelzine, tranylcypromine
Selective b: selegiline patch
2 week washout when switching to antidepressant, or 4 wks for fluoxetine
Which antipsyches are approved for adjunct antidepressant
Aripiprazole, brexpiprazole, seroquel
Data for risperidone
Also olanzapine +fluoxetine for treatment resistant depression
Lithium pregnancy
Avoid in first trimester if possible
Drugs causing lithium tox
Ace, nsaid, diuretic,
Decreases lithium: theophyline
Dayvigo (lemborexant)
orexin blocker
Insomnia
Amifostine
Prevents nephrotoxicity from cisplatin
Mesna
Ifosfamide and cyclophosphamide
Prevents hemorrhagic cycatitis
Leucovorin
Give with mtx- rescues normal cells
Also with 5-FU- improves activity
Separate from glucarpidase
Glucarpidase
Treats toxic mtx levels
Separate from leucovorin
