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BCP > BCP clin med wk 3 > Flashcards

BCP clin med wk 3 Flashcards

1
Q

what kind of chemotherapy is given to destroy left over cells after surgical excision

A

Adjuvent chemotherapy

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2
Q

what kind of chemotherapy is given prior to a surgical procedure to shrink the tumor

A

Neoadjuvant

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3
Q

what are the top 3 most common cancers in men

A

prostate, lungs and bronchus and colon and rectum

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4
Q

what are the top 3 cancers in women

A

breast, lung and bronchus, and colon and rectum

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5
Q

what are the USPSTF screening recommendations for prostate and testicular CA

A

recommends against

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6
Q

what are the USPSTF screening recommendations for cervical CA

A

21 to 65 years with cytology (Pap smear) every 3 years or, for women age 30 to 65 years who want to lengthen the screening interval, screening with a combination of cytology and human papillomavirus (HPV) testing every 5 years.

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7
Q

what are the USPSTF screening recommendations for breast CA

A

biennial screening mammography for women 50-74 years.

Self exam

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8
Q

what are the USPSTF screening recommendations for colon CA

A

using fecal occult blood testing, sigmoidoscopy, or colonoscopy in adults, beginning at age 50 years and continuing until age 75 years.

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9
Q

what are the USPSTF screening recommendations for lung CA

A

low-dose computed tomography (LDCT) in adults aged 55 to 80 years who have a 30 pack-year smoking history and currently smoke or have quit within the past 15 years; D/C if not smoked for 15yrs

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10
Q

what is the TNM method for staging solid tumors

A

location, size and level of tumor invasion (T), absence or presence and extent of nodal mets (N), and presence or absence of systemic mets (M)

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11
Q

what is stereotactic radiosurgery

A

high single dose of radiation to a limited volume using rigid mobilization coordinating system

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12
Q

what is stereotactic radiosurgery used for

A

tx of intracranial lesions, meningiomas, gliomas, and arteriovenous malformations (AVM)

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13
Q

define paraneoplastic syndrome

A

features of dz that can’t be attributed either to the CA’s direct effects or metastatic properties

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14
Q

what is cushing syndrome and what kind of CA is it associated with

A

excessive adrenocorticoids ACTH associated c/ small cell lung CA
moon face, buffalo hump

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15
Q

what is carcinoid syndrome

A

excessive serotonin production associated c/ neuroendocrine tumors
freq met to liver, intestines and lungs
flushing, wheezing, diarrhea

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16
Q

what paraneoplastic (PNS) syndrome is ass. c/ lung, breast, kidney, and other CA is related to PTH and can result in sudden death due to cardiac arrhythmia or asystole

A

hypercalcemia

17
Q

what PNS is seen most often in small cell lung CA, is the result of ectopic ADH, ANP production and can result in altered sensorium, coma, and death

A

hyponatremia

SIADH (syndrome of inappropriate antidiuretic hormone)

18
Q

what is another name for Lambert-Eaton syndrome and what is it

A

myasthenic syndrome
defective release of acetylcholine in response to N. impulse. weakness in proximal m. of the limbs; ass c/ small cell carcinoma- lung GI

19
Q

what is the mechanism of action for the cell cycle specific agent Antimetabolites

A

competes with purine or pyrimidine analogs by getting incorporated into DNA or RNA, thus inhibits synth e.g. methotrexate, fluorouracil

20
Q

what is the mechanism of action of topoisomerase II inhibitor

A

binds to topo II and causes DNA strand breaks. e.g. doxorubicin, etoposide

21
Q

what antimicrotubule agent promotes formation of microtubules and prevents separation

A

paclitaxel
P- Promotes formation
Prevents separation

22
Q

what kind of agent is vincristine and how does it work

A

it is an antimicrotubule agent and acts by binding tubulin and inhibits microtubule assembly

23
Q

how does the folate antagonist methotrexate work

A

inhibit DNA synth, repair, and cellular replication.

24
Q

what are some notable ADE of methotrexate

A

acute kidney injury, mucositis, elevated LFTs, rash

25
Q

what is the MOA of the pyrimidine analogue fluorouracil

A

antimetab that interferes c/ DNA and RNA synth

26
Q

stomatitis, GI ulcer, hand-foot syndrome, cardiotoxicity, angina are ADEs ass. c/ what drug and class

A

fluorouracil - a pyimidine analogue

27
Q

how does the anthracycline

doxorubicin work

A

inhibits topoisomerase II and intercalates into DNA/RNA, powerful iron chelator- binds to DNA cell membrane, produces free radicles to cleave DNA and cell membranes

28
Q

what are some notable ADEs for the anthracycline doxorubicin

A

cardiotoxicity, extravasation potential, secondary malignancies, hepatic fcn impairment, myelosupression

BCP (2 decks)

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