BCP clin med wk 2

Question 1

what is hemophilia

Answer 1

an inherited bleeding disorder caused by deficiency of coagulation factors VIII (A), factor IX (B), or XI (C)

Question 2

what acquired coagulation disorder results in an inc PT and low lvl of clotting factors II, VII, IX, X

Answer 2

vit K deficiency

Question 3

a normal factor V lvl, in spite of dec in activity of factors II, VII, IX, and X suggests what dz

Answer 3

vit K deficiency; in coagulopathy of liver dz there would be dec synth of V as well as II,VII, IX, and fibrinogen

Question 4

what is aplastic anemia

Answer 4

bone marrow failure from supresion or injury to hematopoietic stem cell

Question 5

Uncontrolled local or systemic activation of coag- leads to depletion of coag factors, fibrinogen and thrombocytopenia as platelets are activated and consumed in what dz

Answer 5

DIC

hospitalized pts, ass. c/ sepsis, CA, trauma, burns

Question 6

what 3 things suggest the presence of a thrombotic microangiopathy

Answer 6

thrombocytopenia, hemolytic anemia, and renal dz

Question 7

what is the classic pentad of TTP

Answer 7

The classic pentad of TTP consists of fever, microangiopathic hemolytic anemia, TTP, renal disease, and central nervous system symptoms

Question 8

what are the 4 criteria for the classification of Henoch-Schonlein Purpura

Answer 8

1. palpable purpura
2. age at onset<20yrs
3. bowel angina
4. vessel wall granulocytes on bx