BCL-2 Targetting Flashcards
1
Q
What is the gene translocation associated with human follicular lymphoma?
A
t(14;18)
2
Q
Where do Bcl-2 proteins reside within a cell?
A
On the outer mitochondrial membrane, the ER membrane and the nuclear envelope
3
Q
What is important about the location and exposure of Bcl-2 proteins wthin a cell?
A
The bulk of the protein exposed to thecytoplasm in all of the locations
4
Q
What does overexpression of bcl-2 in B cells, T cells, or both achieve?
A
Avoidance of apoptosis, but also some protection against cytotoxic stimulus eg chemotherapy agents
