BB Ch30 - Animal Models in Research Flashcards
1
Q
- Analogous processes relate
A
one structure or process to another
2
Q
- Homologous processes reflect
A
counterpart genetic sequences
3
Q
- Animal models characterized by: normal animals with physiologic mechanisms similar to those of humans or abnormal animals that arise naturally through mutation(s) are called:
A
spontaneous
4
Q
6. Name the common animal model with their disease: BB Wistar rats Wantanabe rabbits New Zealand Black/White mice Gunn rat SCID mice
A
BB Wistar rats – type I diabetes mellitus
Wantanabe rabbits – hypercholesterolemia
New Zealand Black/White mice – autoimmune disease
Gunn rat – hereditary hyperbilirubinemia
SCID mice – severe combined immunodeficiency
5
Q
- The assay developed using X. laevis embryos and larvae to document developmental abnormalities associated with environmental chemicals is called:
A
frog embryo teratogenesis assay: Xenopus (FETAX)
6
Q
- Oncornavirinae, Lentivirinae, and Spumavirinae are the three subfamilies of:
A
retroviruses
7
Q
- This subfamily of virus is known to infect and cause cancer in multiple species:
A
ocornavirinae
8
Q
- This species has been used extensively for studies in development because their embryos are transparent, each clutch contains 50-100 embryos, and they are amenable to large-scale mutagenesis:
A
zebrafish
9
Q
- A variety of _________ have been developed to control the expression of transferred genes in transgenic animals.
A
promoters
10
Q
- Mice cloned from embryonic stem cells rather than from the low-passage primary cell cultures used in the past show
A
mitochondiral heterogeneity
11
Q
- The nematode in which multiple induced mutations were found to extend life span is:
A
Caenorhabditis elegans
12
Q
- Decrease in DNA telomere length and accumulation of extrachromasomal rDNA circles has been associated with
A
aging/decrease in lifespan
13
Q
- Mutations for the gene for this protein have been found in human families with familial Alzheimer’s disease
A
amyloid precursor protein
14
Q
- He perceived the defects inherent in the scholastic method practiced before him and set the tenets for what would become hypothesis testing.
A
Francis Bacon
15
Q
- Serendipity contributes to important discoveries: the cause of beriberi was discovered to be a deficiency of this vitamin after chickens fed polished boiled rice developed a similar condition.
A
thiamin