basics exam 1

Question 1

what are biomaterials

Answer 1

substances engineered for directing the course of any therapeutic or diagnostic procedure

Question 2

what can biomaterials be

Answer 2

metallic, polymeric, ceramic
natural or synthetic or hybrid
alive or lifeless

Question 3

what are metallic biomaterials

Answer 3

including pure metals and alloys: SS, nickel, titanium, nitinol

Question 4

what are polymeric biomaterials

Answer 4

collagen, PDMS, PCL, alginate, chitosan

Question 5

what are ceramic biomaterials

Answer 5

ceramics and glass: alumina, hydroxyapatite, cilica

Question 6

what are types of carbon allotropes

Answer 6

diamond, graphite/graphene, fullerene/buckyball, buckytube/carbon nanotube

Question 7

what do biomaterials study

Answer 7

materials and the science and engineering of the interactions between materials and biological systems + biocompatibility + regulations

Question 8

what is the general flow of developing biomatierals

Answer 8

1. synthesis/fabrication of biomaterials
2. in vitro characterization of surface and bulk properties - mechanical, chemical, morphological
3. in vitro characterization w living cells/tissues in culture + viability, proliferation, function, and stemness/differentiation (for stem cells only)
4. in vivo tests using appropriate models (needing IACUC)
5. studies using human subjects (need IRB or FDA approval)

Question 9

what in vivo animal models are used for bone regeneration

Answer 9

rabbit, mouse, rat

Question 10

what in vivo animal models are used for neurological regeneration/stimulation

Answer 10

rats

Question 11

what in vivo animal models are used for ophthalmological lenses

Answer 11

rabbits