Basics

Question 1

LH stimulates this cell, mostly?

Answer 1

Leydig Cells

Question 2

FSH main target cell?

Answer 2

Sertroli Cell

Question 3

LH main function?

Answer 3

Stimulate Leydig Cells to ⬆️TESTOSTERONE

Question 4

FSH main function?

Answer 4

Stimulate Sertoli Cells to ⬆️Spermatogenesis

Question 5

Negative feedback for FSH?

Answer 5

Inhibin B (Sertroli Cells)

Question 6

Enzyme necessary for conversion of Testosterone to DHT?

Answer 6

5alpha-reductase

Question 7

LH/FSH use this common signaling pathway?

Answer 7

Gs - cAMP

Question 8

DHT Physiologic Effects?

Answer 8

1. Differentiation of male external genitalia (penis, scrotum) + prostate
2. Male pattern baldness
3. ⬆️Sebaceous gland activity
4. ⬆️NO synthase on penis

Question 9

Enzyme necessary for the conversion of testosterone to estrogens ?

Answer 9

Aromatase

Question 10

Estradiol function in spermatogenesis?

Answer 10

1. Growth and Maturation of Sperm

Question 11

Sertoli Cells needs MAINLY these 2 hormones for the proper formation and maturation of sperm?

Answer 11

1. FSH

2. Testosterone (from Leydig Cells)

Question 12

Testosterone synthetic form?

Answer 12

Methyl-Testosterone

Question 13

Name 2 Adrenal androgens ?

Answer 13

1. DHEA

2. Androstenedione

Question 14

Main sites of aromatization?

Answer 14

1/3 in Sertoli Cells and 2/3 peripheral tissues (adipose tissue)

Question 15

Sertoli Cell tumors have ⬆️levels of the following Hormone?

Answer 15

Estradiol!!! (⬆️aromatase)