Basic science Flashcards
basic science, introduction to blood, ANS
what’s particular with the dilantin and opioids in regards to therapy
They’re effective therapies that have been used for decades or millennia without an understanding of their underlying molecular mechanism of action
when did the idea that ongoing study of the structure and function of the human body could improve medical practice emerged ?
Renaissance
what was Popper’s view of the scientific method ?
no experiment can prove a hypothesis true or even increase our confidence in it. Experiments can only prove hypothesis false.
does science in practice conform to Poppers formula ?
No. Science doesn’t always involve explicit testing of hypotheses. Furthermore, hypothesis testing doesn’t merely exclude false hypotheses. It can also increase our confidence in hypotheses we believe are correct.
where are Nav1.7 channels selectively expressed ? what are they ?
in nociceptors (voltage-gated sodium channel)
Inherited erythromyelalgia (IE)
disorder characterized by episodes of redness and pain in the feet and hands. It can often be triggered by warmth or mild exercise.
Is IE hereditary ?
Yes (inherited erythromyelalgia, you dumb)
What cause IE ?
mutations in the Nav1.7 sodium channel (shift the voltage-dependance of the channel to activate to more negative potential; the channel is easier to open)
what causes congenital insensitivity to pain ?
mutation in Nav1.7 that cause non-functional channels
how these data about Nav1.7 are relevant to clinical practice ?
drugs that selectively inhibited Nav1.7 might be especially effective for treating pain.
the 2 numbers you need to remember for cell size (e.coli and red blood cells)
- e.coli is 1 micrometers
- a red blood cell is 7 micrometers
4 primary tissues that are constituting organs and organ systems
- epithelia
- connective tissue (fills space between epithelia)
- muscle (within connective tissue)
- nervous tissue (within connective tissue)
what’s a glycocalyx
cell coat of carbohydrates
ribosome role
translate mRNA into protein (situated on the rER)
sER role
detox and lipid metabolism and synthesis and calcium storage
difference between sER and rER
the sER is way more tubular, less linear
golgi apparatus role
transformation post-transcription pour pouvoir envoyer les protéines nouvellement construite dans la matrice extracellulaire (transport of proteins through cell, and secretion)
- cells goes from CIS TO TRANS
heterochromatin
when the DNA is condensed
euchromatin
when the DNA is dispersed, for transcription
3 main types of cytoskeleton and their role
- microtubules : primary organisation
- intermediate filaments : structural support
- microfilaments : cell movement (like actin)
microtubule is pat of what structure important for mitosis ?
centrosome (important for formation of mitotic spindle)
what is always at the base of the epithelia ?
basement membrane (basal lamina)
how to you name the different kind of epithelium ?
always name them from the shape of the cells that are on the lumen side
what’s the epithelium of the skin ?
stratified squamous (keratinized) : a coat of dead cells on top of alive ones
different cell shape for epithelium
- squamous (mou, rond)
- cuboidal (cube)
- columnar (colonnes)
different cell number for epithelium
- simple (une couche)
- stratified (+ une couche)
- pseudostratified (tous touche à la BM, mais pas organisé pcq plein de petites cellules qui poussent)
different stratum epithelium of the skin
from the top of the skin
- stratum CORNEUM
- stratum GRANUSOLUM
- stratum SPINOSUM
- stratum GERMINATIVUM
- basement membrane
most commun type of connective tissue ?
collagen fibrils
what are the 2 types of connective tissue ? Qu’est-ce qui les différencient ?
- CT proper : loose, intermediate, etc.
2. CT specialized : + minerals - bone, cartillage, teeth.
what’s amorphous ground substance ?
everything else in the EM (between fibres, resists compressive forces)
what are elastic fibre useful for ? what’s it 2 units of construction ?
- what makes the blood vessel retrack (and other organs)
- made of microfibrils and elastin
mast cells
cells waiting for allergens and release histamine/heparin/leukocyte chemotactic factors
lysosome role
membranous vesicules of hydrolitic enzymes used for the controlled degradation of macromolecules
mesenchymal cells
stem cells that lie in the EM, adult stem cell (can make anything tissue)
endosome
deliver their contents to lysosomes via the endocytic pathway
peroxisomes
produce hydrogen peroxide and then use it to oxidaze a variety of other substrate such as alcohol and other toxic molecules that enter the bloodstream
what do fibroblast make ?
collagen and elastic fibers
roles of binding and connective tissue
- connects tissues and provide a flexible support
- nutritive and excretory role
- role in the defense of the body against infection
cells of connective tissue
- mesenchyme
- fibroblast/fibrocyte
- macrophage
- mast cell
- plasma cell
- adipocyte
plasma cells
specialized in synthesis of proteins as antibodies
where do the nerves of parasympathetic systems are ?
cranio-sacral
where do the nerves of sympathetic systems are ?
thoraco-lumbar