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Ortho > Basic Science > Flashcards

Basic Science Flashcards

1
Q

Importance of MMP 13

A

Degrades cartilagenous extracellular matrix

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2
Q

Antibody to sclerostin

A

Romosozumab

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3
Q

Mnemonic to memorize youngs modulus

A

Ceramic cost could cement poly to cancel her telephone carrier

Ceramic
Cobalt
Stainless steel
Cortical bone
Cement
Poly
Cancellous bone
Tendon
Cartilage

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4
Q

Component of bone that is responsible for compressive strength

A

Hydroxyapetite

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5
Q

Plates: Stiffness proportional to ____ power

A

third

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6
Q

Nails: Stiffness proportional to ____ power

A

fourth

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7
Q

Importance of SHH

A

Responsible for radial/ulnar
High SHH makes pinky, low makes thumb

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8
Q

Disorder of SHH

A

Responsible for fibular hemimelia

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9
Q

Fibular hemimelia characteristics

A
  • Anteromedial tibial bowing
  • Ball in cup tibiotalar joint
  • Loss of lateral rays
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10
Q

AL Tibial bowing

A

“Always look”
Neurofibromas

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11
Q

AM tibial bowing

A

“Absent/missing”
Fibular hemimelia

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12
Q

PM tibial bowing

A

“Probably mild”
Physiologic, calcaneovalgus foot

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13
Q

Gene responsible for Nail Patella syndrome

A

LMX1B

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14
Q

Defect in multiple epiphyseal dysplasia

A

COMP

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15
Q

Differential for multiple epiphyseal dysplasia

A

Legg-Calve-Perthes

  • Differentiate by bilateral involvement
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16
Q

Double layered patella is pathognomonic for

A

MED

17
Q

Importance of type X collagen

A

Mineralization

18
Q

Dumbbell shaped femurs

A

Kniest syndrome

19
Q

Dwarf with short trunk and normal arms and limbs?

A

Spondylioepiphyseal dysplasia congenita

  • varus hips, scoliosis
20
Q

Disorder of type X collagen

A

Metaphyseal Chondrodysplasia, schmid type
- Metaphyseal flaring
- Affects hypertrophic zone

21
Q

Morqio syndrome

A

“Mork”
Normal IQ
Galactose sulfatase
Keratin Sulfate

22
Q

Gaucher disease

A

Beta glucocerebrosidase
Erlenmyer flask femurs
Osteonecrosis of femoral head

Tx: Bone marrow transplant

23
Q

Differential for a tall person

A

Marfans
- AD
- Superior lens ectopia
- Loose joints

Homocystenuria
- AR
- Inferior lens ectopia
- Stiff joints

24
Q
A

Ortho (5 decks)

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