Basic science Flashcards
What is the pre-cursor of leukotrienes?
Arachidonic acid via 5-lipoxygenase
What functions are leukotrienes related to?
Inflammatory response
Slow-reacting substances of anaphylaxis
What mediates the release of platelet-aggregating factor from platelets during the inflammatory cascade?
Leukotrienes
What is the most likely source of re-epithelialization of the donor site of an STSG?
Multipotent stem cells that primarily reside in hair follicles.
Function of cytotoxic T-cells (CD8+)
Survey for defective or infected cells.
Binds to them via CD8+ receptor.
CD3 is expressed by all cells of
T-cell lineage
What are the two mechanisms by which cytotoxic (CD8+) T-cells kill infected cells?
- Release of lysosomal granules containing perforin (Ca2+ dependent)
- Apoptosis via CD95 (Fas) surface receptor (Ca2+ independent)
What does an immature CD8+ T cell need to bind to to promote maturation into cytotoxic T-cell?
Major histocompatibility complex I (MHC I)
Also known as HLA-I
What peptide is the primary inhibitor of the gastric phase of exocrine pancreatic response?
Somatostatin
What is the most potent stimulator of exocrine pancreatic enzymes?
Cholecystokinin
What is the most potent stimulator of pancreatic bicarbonate?
Secretin
Hormone secreted from posterior pituitary in response to stress
ADH (vasopressin)
- Vasoconstriction, increase SVR
- Increase fluid reabsorption in kidneys, increase blood volume
Hormones released from anterior pituitary in response to stress
GH and ACTH
- Increase Cortisol release from adrenals
Actions of Angiotensin II
- Vasoconstriction
- Decrease GFR leading to water retention
- Increase cardiac output and blood pressure.
Where does aldosterone insert its action?
Increase Na+ and water reabsorption in the distal convoluted tubule of the renal cortex.
