Basic Sci Mood Flashcards
poo
Tianeptine increased swimming time in forced swim test (antidepressant activity)
Samuels et al 2017
Dryburgh + Martin said……
Tianeptine enhances place recognition
Zhang et al., 2013
Tianeptine enhances AMPAR-dependent synaptic transmission which is sustained (LTP)
D1 - reinforces behaviour + is stimulation is rewarding
D2 - inhibits behaviour + is aversive
D1 and D2 role in NAc
Chronic stress increases D2 dendrites
Francis et al., 2014
In chronic social defeat stress model, increasing D1 activity rescues depression-like behaviour
Francis et al., 2015
Chronic social defeat stress findings…
Inhibit accumbal D1 activity, enhances D2. Depression like behaviour
IEGs marker of…
neuronal activity
IEGs decreased in prefrontal cortex of people with depression (decreased neuronal activity)
Covington et al., 2010
IEGs reduced in CSDS model but interestingly NOT in unsceptible (resilient) mice
Covington et al., 2010
Activation of the PFC in depressed-like mice had significant reversing effects
Covington et al., 2010
Johnston et al., 2015
Hippocampus overactive during loss events
Covington et al., 2010
IEGs reduced in CSDS model but interestingly NOT in unsceptible (resilient) mice
IEGs decreased in prefrontal cortex of people with depression (decreased neuronal activity)
Activation of the PFC in depressed-like mice had significant reversing effects
CSDS resilient mice have attenuated ventral hippoactivity
Bagot et al., 2015
Induced LTD of ventral hippocampus promotes resilience whereas upregulation promotes susceptibility
Bagot et al., 2015
