BASIC SCI

Question 1

myofibrils activation order

Answer 1

1. type 1 slow oxidative
2. type 2a intermediate
3. type 2b fastest most powerful

Question 2

most powerful myofibil

Answer 2

type 2b

Question 3

osteoblasts activate hematopoietic stem cell pathway via

Answer 3

Jagged 1 - Notch pathway

Question 4

in scoliosis surgery what improves apical translation

Answer 4

90 deg rod rotation

Question 5

collagen fibril size molecule

Answer 5

decorin

Question 6

what is responsbile for tendon crimp

Answer 6

elastin

Question 7

what deposits elastin

Answer 7

fibrillin

Question 8

fxn of Sharpey fibers

Answer 8

anchor periosteum to bone/tendon OR ligaments to bone

Question 9

fxn of calcitonin

Answer 9

inhib sclerostin, inhib osteoclast apoptossis causes osteoporosis

Question 10

fxn of sclerostin

Answer 10

inhib bone formation by inhib Wnt pathway

decr osteoblasts

Question 11

deformation of material by force that acts on it

Answer 11

strain

Question 12

material w different properties based on direction object is loaded

Answer 12

anisotropy

Question 13

force over known area

Answer 13

stress

Question 14

D-zone test used to identify inducible resistance to what abx

Answer 14

clindamycin

Question 15

incr cross linking of UHMWPE

effect on wear or toughness

Answer 15

decr both

Question 16

mechanism of denosumab

Answer 16

inhib RANKL

Question 17

how does size and cellularity change in nucleus pulposus proportional to intervertebral disc after birth

Answer 17

decr size and cellularity

Question 18

major diff btwn thrombogenesis in ortho vs other surgeries

Answer 18

decr antithrombin III

Question 19

wear btwn 2 implant surfaces designed to be in contact

Answer 19

adhesion wear

Question 20

wear btwn 2 diff metals not designed to be in contact

Answer 20

corrosion

Question 21

abrasive wear when particulates become entrapped and cause wear at articulating surfaces

Answer 21

third body wear

Question 22

annealing vs remelting effect on crystal formation of UHMWPE

Answer 22

annealing = incr
remelting = decr crystals

Question 23

sequestrum vs involucrum

Answer 23

sequestrum = infected dead bone

involucrum = new bone around infection

Question 24

chondroitin vs keratan sulfate changes w age

Answer 24

decr chondroitin 
incr keratan (replaces chonroitin)

Question 25

type 1 error

Answer 25

reject null when it is true

Question 26

type 2 error

Answer 26

accept null when it is false

Question 27

blood suppply to scaphoid primarily from

Answer 27

dorsal carpal br of radial artery

Question 28

in physeal injury progression of injury across physis starts

Answer 28

zone of provisional calcification then widening of hypertrophic zone then proliferative zone

Question 29

collagen fiber orientation in superficial vs deep zone

Answer 29

superficial = parallel deep = perpendicular