BASIC SCI Flashcards
myofibrils activation order
- type 1 slow oxidative
- type 2a intermediate
- type 2b fastest most powerful
most powerful myofibil
type 2b
osteoblasts activate hematopoietic stem cell pathway via
Jagged 1 - Notch pathway
in scoliosis surgery what improves apical translation
90 deg rod rotation
collagen fibril size molecule
decorin
what is responsbile for tendon crimp
elastin
what deposits elastin
fibrillin
fxn of Sharpey fibers
anchor periosteum to bone/tendon OR ligaments to bone
fxn of calcitonin
inhib sclerostin, inhib osteoclast apoptossis causes osteoporosis
fxn of sclerostin
inhib bone formation by inhib Wnt pathway
decr osteoblasts
deformation of material by force that acts on it
strain
material w different properties based on direction object is loaded
anisotropy
force over known area
stress
D-zone test used to identify inducible resistance to what abx
clindamycin
incr cross linking of UHMWPE
effect on wear or toughness
decr both
mechanism of denosumab
inhib RANKL
how does size and cellularity change in nucleus pulposus proportional to intervertebral disc after birth
decr size and cellularity
major diff btwn thrombogenesis in ortho vs other surgeries
decr antithrombin III
wear btwn 2 implant surfaces designed to be in contact
adhesion wear
wear btwn 2 diff metals not designed to be in contact
corrosion
abrasive wear when particulates become entrapped and cause wear at articulating surfaces
third body wear
annealing vs remelting effect on crystal formation of UHMWPE
annealing = incr remelting = decr crystals
sequestrum vs involucrum
sequestrum = infected dead bone
involucrum = new bone around infection
chondroitin vs keratan sulfate changes w age
decr chondroitin incr keratan (replaces chonroitin)
type 1 error
reject null when it is true
type 2 error
accept null when it is false
blood suppply to scaphoid primarily from
dorsal carpal br of radial artery
in physeal injury progression of injury across physis starts
zone of provisional calcification
then widening of hypertrophic zone
then proliferative zone
collagen fiber orientation in superficial vs deep zone
superficial = parallel
deep = perpendicular
