Basic Principles of Pharm VI & VII

Question 1

What is the most important route of elimination of drug or metabolites?

Answer 1

Renal excretion

Amount of drug excreted = (amt entering tubule)-(amount reabsorbed)

Question 2

glomerular filtration

Answer 2

• only free drugs are filtered

- the amount filtered depends on glomerular blood flow and free drug concentration

Question 3

active tubular secretion

Answer 3

aka active transport.

• one system for acids, one for bases
• exists for endogenous compounds like uric acid or choline

Question 4

active tubular secretion saturation

Answer 4

can occur at therapeutic doses or with overdoses

-changes 1st order process to 0 order processes

Question 5

Equation for first order reaction

Answer 5

v = (Vmax[D])/km+[D]

Question 6

Equation for zero order reaction

Answer 6

v= Vmax

Question 7

passive reabsorption

Answer 7

• especially for lipid soluble drugs
• after free water absorption these are concentrated in the loop of Henle
• reverse concentration gradient occurs