Basic principles Flashcards
1
Q
Passive movement of non protein bound drugs bet blood and extravascular space; affected by drug concentrate and charge
A
Aqueous diffusion
2
Q
What law is related to aqueous diffusion?
A
Fick’s law of Diffusion
3
Q
Most important limiting factor for permeation?
A
Lipid Diffusion
4
Q
Weak acids and weak bases is diffused through?
A
Lipid Diffusion
5
Q
2 pharmacologic implications in Fick’s Law of Diffusion
A
Absorption is faster in organs with 1) larger SA and 2) thinner membranes