Basic Players of the Immune System Flashcards
germ-line encoded pathogen receptors
innate immunity
humoral and cell-mediated responses
adaptive immunity
What is the response time of the innate immune system?
minutes to hours
What is the response time of the adaptive immune system?
5 to 6 days or more
Which lymphocytes are associated with humoral immunity?
B lymphocytes
Which lymphocytes are associated with cell mediated immunity?
T lymphocytes
Name 4 ways antibodies work.
- Neutralize toxins
- Agglutinate bacteria
- Target pathogens for destruction
- Provide passive immunization
Which regions of Abs have only limited variation?
constant regions
Antibody structure consists of:
2 identical heavy chains
2 identical light chains
Intra- /inter-chain disulfide covalent bonds
Fc region of antibodies determine the ___________________ of Ab.
isotype or class
Name the 5 classes of secreted Abs.
IgA
IgD
IgE
IgG
IgM
Which classes of Ab have J-chains?
IgA and IgM
Which class of Ab has the highest avidity?
IgM
Name 4 types of cells developed from common myeloid progenitors.
- RBC
- monocytes
- granulocytes
- megakaryocytes
Name the 4 granulocytes.
- neutrophils
- basophils
- eosinophils
- mast cells
Which cells are derived from lymphoid progenitors? (3)
- B cells
- T cells
(lymphocytes) - NK cells
Cell considered the first responders to infection.
neutrophils
Granules stain with bright pink.
eosinophils
Granules stain with blue.
basophils
Contains both basic and acidic granules.
neutrophils
Are less than 1% of WBCs and are nonphagocytic, with histamine containing granules.
mast cells
Which type of myeloid lineage cell forms platelets?
megakaryocytes
For which cell is the Ag receptor an antibody?
B cells
Clonal selection takes place during the development of which kind of cells?
B and T cells
