Basic Pharmacology

Question 1

What is Km

Answer 1

Michael’s constant - concentration of substrate at which reaction rate reaches 1/2 it’s maximal velocity

Question 2

How do competitive reversible inhibitors affect Km

Answer 2

Increases Km

Question 3

How do non competitive inhibitors affect Km?

Answer 3

Does not change

Question 4

What is clearance

Answer 4

Volume of blood from which drug is cleared per unit time

Question 5

What is volume of distribution

Answer 5

Total volume of drug in body relative to plasma concentration

Question 6

Efficacy defined

Answer 6

Maximal response of a drug

Question 7

Potency defined

Answer 7

Concentration of drug that gives a certain response

Question 8

Drugs that show zero order clearance

Answer 8

Phenytoin
Aspirin
Ethanol

Question 9

What is first order clearance

Answer 9

Rate of clearance of drug directly proportional to concentration of drug

Question 10

What is zero order clearance

Answer 10

Clearance rate remains constant despite concentration of drug

Question 11

2 phases of metabolism

Answer 11

Phases 1 and 2