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Y2C1 Süheyla > Basic immunopathology > Flashcards

Basic immunopathology Flashcards

Y2C1 1 question wlii be asked

1
Q

what is the first line of body defense

A

Innate immunity

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2
Q

components of Innate immunity

what type of cells found in Innate immunity ?

A

Epithelial cells
phagocytic cells
NK cells
plasma proteins
dendritic cells
other innate lymphoid cells

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3
Q

epithelia

epithelial cells also produce_____molevules such as defensins and lymphocytes

A

antimicrobial molecules

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4
Q

phagocyte microbe and protein antigens present___fragments to__cells

A

peptide fragments
T cells

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5
Q

macrophages

effector cell in___&____ immunity

A

cellular & humoral

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6
Q

marophages

phagocyte microbes that oposnized by___or___

A

IgG or C3b

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7
Q

macrophages

__cells activate macrophage and enhance ability to kill ingested microbes

A

T cells

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8
Q

dendritic cells

____dendritic cells under epithelia, interstitia of all tissue

A

interdigitating

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9
Q

dendritic cells

most important___presenting cells for initiating____responses aganist protein antigens

A

antigen presenting
T cells

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10
Q

dandritic cells

follicular dendritic cell present in ?

A

spleen and lymph nodes

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11
Q

Innate lymphoid cells

Innate lymphoid cells are___resident lymphocytes

A

tissue-resident

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12
Q

Innate lymphoid cells

cannot respond to antigens bu instead are activated by____and other mediators produced at sites of tissue damage

A

cytokines

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13
Q

Innate lymphoid cells

are the sources of inflammatory cytokines during early phases of_______reactions

A

immune

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14
Q

ınnate lymphoid cells

____cells are one type of ILC that provide early protection aganist many viruses and intracellular bacteria

A

natural killer

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15
Q

natural killer cell

contain____granules

A

azurophilic granules

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16
Q

natural killer cell

not bear___cell receptor or cell surface__

A

t cell receptor or cell surface Ig

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17
Q

natural killer cell

has ability to kill without____

A

sensitization

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18
Q

natural killer cell

lyse___cells
___infected cells
secreate___

A

tumor cells
virally infected cell
secrete cytokines

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19
Q

plasma proteins

____system consist of plasma proteins that are activated by microbes

A

complement system

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20
Q

plasma proteins

contains
_____binding lectin
_____protein

A

mannose-binding
C-reactive protein

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21
Q

Innate immunity

2 pattern exists which are ?

A

pathogen associated molecuar patterns
damage-associated molecular patterns

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22
Q

PAMPs pathogen associated molecular patterns

molecular structures or molecules that are shared by most pathogenic____&____

A

virus & bacteria

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23
Q

cellular receptor that recognize molecules released by____and_____cells

A

injured and necrotic cells

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24
Q

___recognize molecules that released from injured or necrotic cells

this patterns called damage associated molecular patterns

A

leukocytes

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25
Q

Toll like receptors TLRs

___&___cells recognize components of microbes by cellular receptors

A

leucocytes & epithelial cells

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26
Q

Toll like receptors TLRs

also known as______receptors

A

recognition

27
Q

toll like receptors TLRs

present in plasma_____&_____vesicles

initiate cellular response to microbes

A

membrane and endosomal vesicles

28
Q

NOD nucleotide binding oligomerization domain-like receptors

intracellular sensors of______patterns

Nod not only receptors but inflammasome

A

pathogen associated molecular patterns

29
Q

İnnate immunity:receptors

C-type lectin receptors expressed on plasma membrane of_____&____cells

A

macrophages & dendritic cells

30
Q

C-type lectin receptors(CLRs)

can detect___glycans and____inflammatory reactions to fungi

A

fungal glycans & elicit

31
Q

RIG-like receptors(RLRs)

located at____of most cell types

A

cytosol

32
Q

RIG-like receptors(RLRs)

detect nucleic acids of____that replicate in____of infected cells

A

virus
cytoplasm

33
Q

pattern recognition receptors

are located in all cellular compartments where microbes may be present:

A

plasma membrane receptors
endosomal receptors
cytosolic receptors

34
Q

pattern recognition receptors

plasma membrane receptors can detect____microbes

A

extracellular

35
Q

Innate immunity:after recognition

TLR signal cause activation of_____factors

known as transcription factors

A

NF-kB

nuclear factor

36
Q

Innate immunity:after recognition

NF-kB cause production of__and proteins that stimulateactivities of cells

A

cytokines
microbicidal activities

37
Q

adaptive immunity

cellular immunity protect aganist
______microbes and______

A

intracellular microbes and cancers

38
Q

adaptive immunity

cellular immunity mediated by ?

A

T lymphocytes

39
Q

adaptive immunity

humoral immunity protect aganist ?

A

extracellular microbes and their toxins

40
Q

adaptive immunity

mediated by ?

A

B lymphocytes

and their secreated products antibodies (İmmunoglobin Ig)

41
Q

lymphocytes

____lymphocytes not encountered with ag

native immunologically unexperienced

A

mature

42
Q

mature lymphocyte after activated by ag

____cells eliminate microbes
_____cells live in a state of awareness

A

effector
memory

43
Q

T lymphocyte:helper T lymphocytes

stimulate B lymphocytes to?

A

make antibodies
activate other leukocytes

44
Q

T lymphocyte

3 type exist name them

A

helper T
cytotoxic(killer) T
regulatory T

45
Q

regulatory T lymphocytes

limit___responses and prevent reactions aganist____antigens

A

immune responses
self antigens

46
Q

cytotoxic T lymphocytes

kills____cells

A

infected

47
Q

T lymphocyte

generated from immature precursors in ?

A

thymus

48
Q

T lymphocyte

Cell zone located at ?

A

lymph node and spleen

49
Q

T lymphocyte

each T cell recognize ag by ____specific T cell receptor

A

ag-specific

50
Q

T cell receptor

consist of_____or_____pp chain

A
51
Q

T cell receptor complex

associated with group of proteins called ___complex

which initiate activating signals

A

CD3

52
Q

T cell receptor complex TCR

all proteins of CD3 complex are____in all T cell

they do not contribute to specificity

A

identical

53
Q

TCR diversity

generated by_________of genes encoding TCR chains

A

somatic rearrangement

54
Q

TCR diversity

every somatic cell has TCR genes in____configuration

A

germline

55
Q

TCR diversity

rearrengement occur only in__cells during development in thymus

A

T cells

56
Q

TCR receptor types

aB TCR recognize____via_____complex(MHC)of___presenting cells

A

antigens
major histocompatibility complex
antigen-presenting cells

57
Q

TCR receptor types

____TCR recognize____,____small molecules w/o requirement of___proteins

A

MHC

major histocompatibility complex

58
Q

gamma&delta T cells

found at____surfaces of GI respiratory,urogenital mucosa
protection aganist___

A

epithelial surface
protection aganist microbes

59
Q

T cells receptors

CD4 & CD8 required to initiate signals that activate___cells
expressed on___T cells

A

T cells
alpha&beta T cells

60
Q

T cell receptor functions

CD4>_helper
secreates____

A

T helper
cytokines

61
Q

B lymphocytes

__ synthesis and secretion
B-cells recognize antigens via____complex which includes Ig_ & Ig_
after antigen recognization B cell converts into___cell

A

Ig synthesis
antigen receptor complex
includes IgM &IgD
B-cell converts into plasma cell

Ig is the mediator of humoral immunity

62
Q

B-cell receptor complex

composed of membrane Ig__&__
CD__ is a receptor for a complement component

A

IgM&D
CD21

63
Q
A

Y2C1 Süheyla (3 decks)

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