Basic Concepts Of Transmembrane Biophysics Flashcards
What is the lipid raft hypothesis?
local lipid order might be an important constituent in membrane protein recruitment and functionality
The double-layer lipid membrane covered by surface proteins was a model proposed by who?
Danieli and Davison
Who proposed the fluid mosaic model?
Singer and Nicholson
Who proposed a model relying on capillary forces that exist between lipids and proteins leading to domains and aggregates
Morritson and Bloom
What are the applicable physical states?
- solid-ordered
- liquid-ordered
- liquid disordered
The membrane consists of ______ and _______.
lipids; proteins
What is transmembrane biophysics?
phenomena emerging on mesoscopic and microscopic scales
Receptor and channel folding are on what kind of scale, molecular or cellular?
molecular
Mutation impact on function is on what kind of scale, molecular or cellular?
molecular
Elastic constant measurement, relaxation time scales, phase, and cooperative behavior, and domain formation are on what kind of scale, molecular or cellular?
cellular
What is the first law of thermodynamics?
energy of the universe remains the same; cant be created or destroyed
What is the second law of thermodynamics?
an isolated systems entropy will never decrease over time
What is the third law of thermodynamics?
the entropy of a perfect crystal of a pure substance approaches zero as the temperature approaches zero
What factors influence a membrane’s properties?
- heat capacity
- volume and area compressibility
- Bending elasticity
- Capacitance
