Base Exercision Repair Flashcards
1
Q
What is the job of BER?
A
Correct DNA damage
Causes little distortion to DNA helix structure
2
Q
Outline the 5 steps
A
1- exercision of base
2- incision
3-end processing
4-repair synthesis
5-ligation
3
Q
Describe what happens in the exercision of base stage
A
Damage specific DNA glycosylase removed the flipped out damaged base
Leaving an abasic site
4
Q
Describe the incision stage;
A
Removal of all sugar fragments by lyase
5
Q
Describe the end processing stage;
A
Clean up of sugar backbone ends
6
Q
Describe the repair synthesis;
A
Dna polymerase fills the gap
7
Q
Describe the ligation phase;
A
Seal up in the repaired strand
