basal lamina Flashcards
1
Q
define the basal lamina structurally
A
intermingled thin sheet like network of collagen IV, laminins, reinforced by nidogens and proteoglycans
2
Q
what is the basal lamina called in the epithelia
A
basement membrane
3
Q
how is the basal lamina attached to epithelial cell
A
via hemidesmosomes
4
Q
2 functions of the basal lamina
A
physical support, filtering functions
5
Q
structural differences of type IV collagen compared to fibrillar collagen
A
non helical portions that provide flexibility
propeptides not cleaved
dimers and tetramers formed, assembling a network
6
Q
structure of laminins
A
cruciform molecule made of 3 polypeptide chains
ends of the arms can bind collagen and hemidesmosomes
