basal lamina Flashcards

1
Q

define the basal lamina structurally

A

intermingled thin sheet like network of collagen IV, laminins, reinforced by nidogens and proteoglycans

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2
Q

what is the basal lamina called in the epithelia

A

basement membrane

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3
Q

how is the basal lamina attached to epithelial cell

A

via hemidesmosomes

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4
Q

2 functions of the basal lamina

A

physical support, filtering functions

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5
Q

structural differences of type IV collagen compared to fibrillar collagen

A

non helical portions that provide flexibility
propeptides not cleaved
dimers and tetramers formed, assembling a network

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6
Q

structure of laminins

A

cruciform molecule made of 3 polypeptide chains

ends of the arms can bind collagen and hemidesmosomes

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