BAP38 - Non-neoplastic diseases of small and large bowels Flashcards
In ischemic bowel disease, which layer of the bowel is most prone to ischemia? Why?
The mucosa, as it is furthest away from the blood supply
In ischemic bowel disease, there is a hypoxic injury phase and a reperfusion injury phase. Briefly describe what happens in each phase.
Hypoxic injury: little damage
Reperfusion injury phase:
o ↑O2 supply > ↑ROS
o ↑influx of leukocytes and complements > ↑inflammation
Watershed zones like end of arterial supplies are prone to damage. Give 2 examples.
- Splenic flexure: between SMA and IMA
2. Rectosigmoid junction: between IMA and internal iliac artery
What are the 3 types of infarction in ischemic bowel disease? (briefly describe)
- Mucosal
- Mural - mucosal + submucosal
- Transmural - all layers
What is the pathophysiology for mucosal, mural and transmural infarction in ischemic bowel disease?
Mucosal + Mural:
- Systemic hypoperfusion (shock)
- Localized anatomical defects
Transmural:
- Acute occlusion of a major mesenteric injury > infarction
Which of the following about ischemic bowel disease is incorrect?
A. If mucosal/mural infarction is not resolved, it will progress to transmural infarction
B. Patients will experience abdominal pain and melena in all 3 types of infarction
C. Patients with transmural infarction have high mortality (>50%)
D. Patients with transmural infarction may experience sepsis and shock
All of the above
Etiology of ischemic bowel disease can be classified into luminal, mural and extramural. Give examples of each of them (5)
- Luminal
- Embolism: AF as MC factor, - - - Thrombosis (Virchow triads) - Mural
- Atherosclerosis
- Vasoconstriction: secondary to shock or vasoconstrictors (phenylephrine, noradrenaline) - Extramural
- Anatomical defects: volvulus, hernia
Which anatomical site is most vulnerable to arterial embolism? Why?
SMA, greatest velocity of blood flow + most acute angle off the aorta
What are hemorrhoids?
Variceal dilations of anal/perianal venous plexus
Which of the following about hemorrhoids is incorrect?
A. Constipation is a risk factor
B. Pregnancy is a risk factor
C. Portal hypertension is a rare risk factor
D. Patients experience pain in all types of hemorrhoids
E. Patients may experience rectal bleed and pruritus
D: only in external and thrombosed hemorrhoids!
A: because it causes increase venous pressure
What are the differences between external and internal hemorroids? (6)
Location:
- Ex: below the dentate line
- In: above the dentate line
Epithelium
- Ex: squamous epithelium
- In: Columnar epithelium
Pain
- Ex: pain if thrombosed
- In: no pain
Internal hemorrhoids can be further divided into which 4 grades?
Grade 1: no prolapse
Grade 2: prolapse that can be reduced spontaneously
Grade 3: prolapse that can be reduced manually
Grade 4: prolapse that cannot be reduced
What is the definition of angiodysplasia (vascular ectasia)?
AVM (arteriovenous malformation) characterised by tortuous dilatations of submucosal and mucosal veins
Where is the MC site for angiodysplasia in the GI tract?
Caecum and ascending colon (80%) > jejunum and ileum (15%)
Which of the following about angiodysplasia is incorrect?
A. It is associated with end-stage renal failure (ESRF)
B. It is a common cause for LGIB
C. It can be due to degenerative causes
D. It can be due to mechanical causes like peristalsis
E. All recurrent bleeding caused by angiodysplasia is self-limited
E
- 15% experience massive bleeding
D: Mechanical: peristaltic contraction > intermittent obstruction and dilatation of submucosal veins, venules, capillaries > loss of precapillary sphincter function > AVM
What are the 2 types of infective enterocolitis?
- Intestinal tuberculosis
2. Pseudomembranous colitis