Bacterial Infections of Soft Tissue I: Aerobes

Question 1

Reservoir for P. aeruginosa

Answer 1

Water, soil, normal flora of skin

Question 2

What diseases can P. aeruginosa cause?

Answer 2

Nosocomial infection, Endocarditis, Folliculitis, Osteochondritis, Corneal infection

Question 3

What bug causes endocarditis in IV drug users?

Answer 3

P. aeruginosa

Question 4

What bug causes CF pneumonia?

Answer 4

B. cepacia

Question 5

What two bugs cause Syx that range from flulike to fatal septicemia?

Answer 5

B. pseduomallei and B. mallei

Question 6

What bug causes folliculitis from hot tubs?

Answer 6

P. aeruginosa

Question 7

What bug causes catheter-associated UTIs?

Answer 7

B. cepacia

Question 8

What bug causes wound infections?

Answer 8

B. cepacia

Question 9

What bug causes Osteochondritis in foot puncture wounds?

Answer 9

P. aeruginosa

Question 10

What bug causes corneal infection under contacts?

Answer 10

P. aeruginosa

Question 11

What causes foot rot in swamp-deployed military?

Answer 11

B. cepacia

Question 12

What three bugs have environmental reservoirs?

Answer 12

P. aeruginosa, B. cepacia, and B. pseudomallei

Question 13

What is the reservoir for B. mallei?

Answer 13

Horses/Other Livestock

Question 14

What diseases do B. cepacia cause?

Answer 14

CF pneumonia, Cather-associated UTIs, IV-associated septicemia, Wound infections, Foot rot in swamp-deployed military

Question 15

What are the virulence factors for P. aeruginosa?

Answer 15

Exotoxin A (Shuts down protein synthesis), Elastase (degrades cells and immune molecules), Phospholipase C (destroys tissue), Pyocyanin (siderophore [sequesters iron])

Question 16

What are the virulence factors for B. cepacia?

Answer 16

Lipase, metalloproteases, serine proteases: all destroy tissue

Question 17

What are the virulence factors for B. pseudomallei?

Answer 17

Capusle (resist endocytosis), adhesins, fimbriae

Question 18

For which two bugs are there experimental vaccines?

Answer 18

Experimental vaccines exist for CF patients to prevent P. aeruginosa and B. cepacia infections

Question 19

Of the following bugs, which are gram (-) rods? P. aeruginosa, B. cepacia, B. pseudomallei, B. mallei

Answer 19

All of them, bitch.

Question 20

What is similar about P. aeruginosa, B. cepacia, B. mallei, and B. pseudomallei infections?

Answer 20

They all exhibit extreme AB resistance (esp. P. aeruginosa), gram (-) rods, aerobic, Oxidase (+),

Question 21

What two bugs commonly infiltrate hospital solutions?

Answer 21

P. aeruginosa and B. cepacia

Question 22

What is the classic setting for a P. aeruginosa infection?

Answer 22

Hospitals

Question 23

What is the classic setting for a B. cepacia infection?

Answer 23

CF center

Question 24

What is the classic setting for a B. pseudomallei infection?

Answer 24

Travelers/immigrants or Vietnam vets

Question 25

What is the classic setting for a B. mallei infection?

Answer 25

Travelers/immigrants or Animal Handling Hx

Question 26

How can you Dx P. aeruginosa, B cepacia, B. pseudomallei and B. mallei?

Answer 26

Culture and Gram stain

Question 27

What is chronic infection with B. mallei called?

Answer 27

Farcy

Question 28

Describe the culture findings of B. pseudomallei

Answer 28

Exotic crusted morphology

Question 29

What bug synthesizes pyocyanin? What is pyanocyanin?

Answer 29

P. aeruginosa; Virulence factor toxin that sequesters iron.