Bacterial and Viral Vaccines

Question 1

1. Men B (Neisseria Meningitidis B) - Who’s it given to?

What does the Bexsero vaccine contain?
→ What is the problem with this vaccine?

2. Men ACWY - Who’s it given to? What does the vaccine contain?
3. Hib (Haemophilus Influenzae Type B) - What does the vaccine contain?
4. Streptococcus Pneumoniae:
   o Pneumococcal Polysaccharide Vaccine (PPV23) - Who’s it given to? How many strains of the bacteria is it effective against?

o Pneumococcal Conjugate Vaccine (PCV13V) - Who can it be given to? What does the vaccine contain?

Answer 1

1. Newborns with Boosters at 1 year

• Components, including Outer membrane vesicles and Recombinant surface proteins
  → Doesn’t cover all Serotypes of Men B and isn’t cost-effective

2. High-risk groups - Conjugated Capsular Polysaccharides (Component)
3. Type B Capsular Polysaccharides conjugated to Diphtheria/Tetanus Toxoids and Surface proteins
4. o Children >2yrs and at risk adults - Effective against 23 strains

o Children <2yrs - Polysaccharides from 13 most common strains are conjugated to Diphtheria/Tetanus Toxoids and Surface proteins

Question 2

5. DTaP (Diphtheria, Tetanus, Pertussis) - What does the vaccine contain?
6. Influenza - Who’s it given to and Why just this group of people? What does the vaccine contain?
   → Why do new vaccines have to be produced for this every year?
7. HPV (Human Papillomavirus) - What are the 2 vaccines used? What do these vaccines contain?
8. TB - What vaccine is given? What does this contain?

Answer 2

5. Dead, Whole organism of Pertussis and the Components (Adhesins, Toxoids, Surface proteins) of Diphtheria and Tetanus
6. Those at highest risk of serious illness to reduce its spread - Components (Haemagglutinins)
   → Keep up with the virus’s Antigenic drift and shift
7. Gardasil (HPV6/11/16/18), Cervarix (HPV16/18) - Recombinant Capsid L2 protein in Virus-like particles
8. BCG - Live, Attenuated organism