Bacterial Adhesion and Invasion Flashcards
How does Listeria enter host cells?
Uses Internalin A (InlA) and InlB to induce entry via E-cadherin and Met signaling
How does Salmonella enter host cells?
Enters non-phagocytic cells using the SPI-1 Type III Secretion System
How does Shigella enter host cells?
Invades host cells using a Type III Secretion System encoded on the virulence plasmid (pINV).
How does Listeria monocytogenes manipulate host cell processes?
Mechanism: Recruits adherens junction components and clathrin, activates Met signaling.
Effect: Induces cytoskeletal rearrangements for entry.
How does Salmonella typhimurium manipulate host cell processes?
Mechanism: Modulates Rho GTPase signaling pathways (Cdc42, Rac1) using effectors like SopE and SptP.
Effect: Alters host cytoskeleton for entry and invasion.
How does Shigella flexneri manipulate host cell processes?
Mechanism: Subverts host cell structure and function, modulates inflammatory responses.
Effect: Promotes intracellular survival and spread.
How does Listeria monocytogenes affect the host cytoskeleton?
Mechanism: Induces cytoskeletal rearrangements via InlA and InlB.
Effect: Uses actin filaments for motility within the host cell.
How does Salmonella typhimurium affect the host cytoskeleton?
Mechanism: Uses effectors like SipA, SopE, and SptP to modulate actin dynamics and Rho GTPase activity.
Effect: Facilitates entry and invasion of host cells.
How does Shigella flexneri affect the host cytoskeleton?
Mechanism: Triggers actin polymerization through IpaC and other effectors.
Effect: Promotes motility and intracellular spread.
What secretion systems does Listeria monocytogenes use?
Uses proteins like InlA and InlB for entry.
What secretion systems does Salmonella typhimurium use?
Relies on the SPI-1 Type III Secretion System.
What are the pathogenic strategies of Listeria monocytogenes?
Mechanism: Escapes vacuoles, rapidly replicates in the cytoplasm.
Strategy: Uses actin tails for movement within the host cell.
What secretion systems does Shigella flexneri use?
Utilizes a Type III Secretion System encoded on the virulence plasmid (pINV).
What are the pathogenic strategies of Salmonella typhimurium?
Mechanism: Enters and replicates within macrophages.
Strategy: Uses a complex secretion system for invasion.
What are the pathogenic strategies of Shigella flexneri?
Mechanism: Invades host cells, modulates host responses.
Strategy: Promotes intracellular survival and spread, uses actin-based motility.
