Bacteria Flashcards
Prophylaxis vs Therapeutic
I
Systematic approach
I
Confirm the presence of infection
K
Gram Stain
I
Purple/blue
I
Pink/red
I
Specimen examples
P
Meningitis
I
Pneumonia
E
Osteomyelitis
E
UTI
E
Endocarditis
E
Susceptibility testing
E
Help to determine antimicrobial breakpoint
I
Dilution method: Broth microdilution
O
Disk Diffusion
O
Antibiotic concentration gradient method
L
Normal flora:
L
Colonization
O
Contamination
O
Infection
L
Microorganisms that are present in human tissue without
being pathogenic at normal circumstances.
L
Pathogenic organism may exist on the human body without
causing an infection
O
Organism is introduced into the specimen during sample
collection and processing
P
organism invades and damages host tissue resulting in a host
response (signs and symptoms)
L
Patient factors
D
Drug factors
C
The causative pathogen may be different for different age group (Example:
Meningitis)
D
increases risk of lower limp infections
D
with cystic fibrosis
O
Select an antibiotic with good penetration to the infection site:
I
Some side-effect may need to be avoided in certain patient
populations:
L
CNS toxicity with neurological disorders
I
Hematological toxicity
K
Photosensitivity and sun exposure
K
Pharmacokinetics/Pharmacodynamic profile
L
Concentration dependent
V
AUC/MIC
D
Time dependent
D
Cmax/MIC
S
T>MIC
D
Antimicrobials mechanism of action
D
Cell wall
S
DNA/RNA synthesis
S
Folate synthesis
D
Cell membrane
W
Protein synthesis
D
Staphylococcus aureus
Treatment
S
Pseudomonas Aeruginosa
Treatment
S
Enterobacterales ( E.coli, Klebsiella spp. Enterobacter spp. Citrobacter spp.)
Treatment
S
Anaerobes
Treatment
D
Cefazolin
L
Oxacillin/Nafcillin
I
Cephalexin
I
Dicloxacillin
I
Vancomycin
P
Daptomycin
L
Linezolid
O
ceftaroline
I
Piperacillin/tazobactam,
9
Cefepime
O
Ceftazidime
O
Gentamicin
O
Amikacin
P
Levofloxacin
I
Ciprofloxacin
O
Carbapenems
I
Metronidazole
9
Clindamycin
O
Amoxicillin/clavulanic acid
I
Meropenem
P
Monitor response
L
Gram positive cocci
Skin
Oropharynx
GI tract
Gential tract
D
Gram positive rods
Skin
Oropharynx
GI tract
Gential tract
D
Gram negative cocci
Skin
Oropharynx
GI tract
Gential tract
E
Gram negative rods
Skin
Oropharynx
GI tract
Gential tract
D
Streptococcus
F
Corynebacterium
G
Propionibacterium
G
Lactobacillus
G
Micrococcus
G
Enterococcus
G
Peptostreptococcus
G
Neisseria
G
Entericbacilli(somesites),
G
Acinetobacterspp.
F
Haemophilus
K
Bacteroides
L
Entericbacilli
O
Enterobacteriaceae
K
Candidaspp.
K
Gram positive Cocci
cluster
Pairs
Chains
D
Gram positive Bacilli
Small , large
S
Gram negative bacilli
D
Coagulase positive
D
Coagulase negative
C
Streptococcus pneumonia
D
B hemolytic
D
Alpha hemolytic
D
Streptococcus pyogenes
D
Streptococcus agalactiae
D
Virdian streptococcus
D
Listeria
S
Cultibacterim
D
Coynbacterium
D
Clostridium bacillus
D
Lactobacillus
S
Oxidase positive
E
Oxidase negative
S
Haemophilus
S
Moraxella catarrhalis
S
Moraxella spp
S