Bacopa Monnieiri Flashcards

1
Q

What does ‘“perennial’ mean?

A

A plant that lives for more than 2 years

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2
Q

Where is it native to?

A

native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America

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3
Q

What type of herb is it?

A

A creeping herb

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4
Q

Which practice uses bacopa?

A

Ayurveda medicine

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5
Q

What is a. medicine?

A

An ancient indian medicine that is classes by the government as an alternative medicine. Uses herbal remedies with little scientific evidence.

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6
Q

What is it’s alternative name in Ayurveda medicine?

A

Brahmi (after the God)

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7
Q

Is it an aromatic herb?

A

No

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8
Q

Desrcibe its appearance?

A

oblong and 4–6 mm (0.16–0.24 in) thick. Leaves are oblanceolate and are arranged oppositely (opposite deccusate) on the stem. The flowers are small, actinomorphic and white, with four to five petals. Its ability to grow in water makes it a popular aquarium plant. It can even grow in slightly brackish conditions

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9
Q

How can the plant be grown?

A

Hydroponically (using mineral nutrient solutions instead of water to grow plants)

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10
Q

What is its traditional usage in Ayurveda medicine?

A

used in traditional Ayurvedic treatment for epilepsy and asthma.[4] It is also used in Ayurveda for ulcers, tumors, ascites, enlarged spleen, inflammations, leprosy, anemia, and gastroenteritis

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11
Q

Describe its ancient roots briefly

A

Bacopa monnieri was initially described around the 6th century A.D. in texts such as the Charaka Samhita, Atharva-Veda, and Susrut Samhita as a medhya rasayana–class herb taken to sharpen intellect and attenuate mental deficits. The herb was allegedly used by ancient Vedic scholars to memorize lengthy sacred hymns and scriptures.

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12
Q

What is its best known active compound?

A

Bacosides

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13
Q

What is the chemical name for b——-s?

A

dammarane-type triterpenoid saponins

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14
Q

Name 5 out of the 12 analogs of bacosides known currently

A

Other saponins called bacopasides I–XII have been identified more recently.[10] The alkaloids brahmine, nicotine, and herpestine have been catalogued, along with D-mannitol, apigenin, hersaponin, monnierasides I–III, cucurbitacin and plantainoside B.

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15
Q

Go through the most studied constituent bacoside

A

The constituent most studied has been bacoside A, which was found to be a blend of bacoside A3, bacopacide II, bacopasaponin C, and a jujubogenin isomer of bacosaponin C

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16
Q

What did Rastogi et al find to be the bacoside profile of one Bacopa sample?

A

In one Bacopa monnieri sample, Rastogi et al. found this bacoside profile—bacopaside I (5.37%), bacoside A3 (5.59%), bacopaside II (6.9%), bacopasaponin C isomer (7.08%), and bacopasaponin C (4.18%)

17
Q

What special in vitro and microscopic effects has Bacopa been shown to have?

A

In vitro antioxidant and cell-protective effects

18
Q

What has Bacopa been shown to do in animals?

A

In animals, it also inhibits acetylcholinesterase, activates choline acetyltransferase, and increases cerebral blood flow

19
Q

What have several small studies and clinical trials shown?

A

Several studies have suggested that Bacopa monnieri extracts may have protective effects in animal models of neurodegeneration.[18] Small clinical trials in humans have found promising evidence for memory recall but research for other cognitive domains remains in its infancy

20
Q

What toxicological effects has Bacopa been shown to induce?

A

Several studies have suggested that Bacopa monnieri extracts may have protective effects in animal models of neurodegeneration.[18] Small clinical trials in humans have found promising evidence for memory recall but research for other cognitive domains remains in its infancy

21
Q

In humans, what side effects have been discovered?

A

Nausea, increased intestinal motility, and gastrointestinal upset