Background, Healing, Closure, Screening/ Exam Flashcards
What are the functions of the integumentary system?
o “Serves as a barrier to environmental threats such as bacteria, pressure, shear, friction, & moisture”
(Guide to PT Practice)
o Protection/immunity - protects against pathogens, decreases water loss
o Temperature regulation – provides insulation, related to dilation & constriction of blood vessels, sweating
o Sensation – contains various nerve endings, including for pain, light touch, etc
o Assists in VitD synthesis, indicator of VitB levels
Layers of the integumentary system
epidermis
dermis
hypodermis
Layers of the epidermis:
stratum corneum
stratum lucidum
stratum granulosum
stratum spinosum
stratum basale
basement membrane
stratum corneum (epidermis)
-most superficial- primary barrier
-soft keratin-containing, dead squamous cells
-constantly sloughing or shedding
-15-20 layers of dead cells
-can indicate hydration levels
stratum lucidum (epidermis)
-thin, clear layer of dead skin cells
-palms of hands and soles of feet (increased tissue stress areas)
stratum granulosum (epidermis)
layer that contains the transition zone for the development of keratin
-active keratin development
Stratum spinosum (epidermis)
-layer containing spiky or spiny projections
stratum basale (epidermis)
deepest and most continuous layer of the epidermis
1-3 layers of cells thick
regenerates the epidermis –> everything above it
contains a variety of other cells
CELLTYPES: basal cells, keratinocytes, merkel cells melanocytes,
Basement membrane (epidermis/dermis)
layer that separates the epidermis and dermis
Epidermal cell types and appendages
o Melanocytes – produce melanin
–> found in stratum spinosum and stratum basale
o Merkel cells – mechanoreceptors for light touch sensation
–> found in stratum spinosum
o Langerhans’ cells – fight infection
–> found in stratum spinosum
Functions of the dermis
-thickest layer of the skin
FUNCTIONS
▪ Thermoregulation
▪ Storage of water/maintaining hydration
▪ Provides nutrients & waste removal for itself & the epidermis
▪ Houses the epidermal appendages
▪ Assists with infection control
▪ Provides sensation
-hair, nails, sweat glands, and sebaceous glands
What does the dermis contain?
-blood vessels
-lymph vessels
-nerve endings
-epidermal appendages
–> hair
–> sebaceous glands: slow down growth of bacteria; secrete sebum
–> sudoriferous glands–> sweat glands
–> nails
Regions of the dermis
PAPILLARY REGION
-bumpy surface that interdigitates with the epidermis, strengthens the connection
-influences the contours of the skin’s surface
-ex: fingerprints
RETICULAR REGION
- Contains collagen, elastic, & reticular fibers, providing strength, extensibility, & elasticity
- Contains the roots of the hair, sebaceous & sweat glands, receptors, nails, & blood vessels
Hypodermis characteristics:
-subcutaneous tissue
-attaches skin to underlying bone and muscles
-contains loose CT, adipose tissue, and elastin
-contains 50% of body fat
-provides insulation and shock absorption
-Pacinian cells (vibration, deep pressure, proprioception) and free nerve endings for cold and pressure
What is a pacinian cell?
Pacinian corpuscles, also known as Vater-Pacini or lamellar corpuscles, are sensory receptors for vibration and deep pressure and are essential for proprioception
-found in the hypodermis
Why do we care about the integumentary system/wound care?
skin abnormalities–> can indicate more global disease
appearance and quality can indicate overall health
-PT can specialize in wound care
-profound effects on our patients and on the healthcare system
Risk factors for inadequate wound healing:
-comorbidities
-nutrition or malnutrition –> appropriate protein and calorie intake
-obesity- extra tissue gets less blood flow the further out the tissue has to go
-smoking, alcohol, and/or drug use
-sedentary or limited mobility
-impaired sensation
-risk-prone behavior
Extrinsic factors impacting wound healing:
-shoes - condition and fit
-orthotics and prosthetics
-seating
-hairstyles
What kinds of health conditions can impact the integumentary system?
cardio - venous/arterial insufficiencies
endocrine/metabolic - DM
neuromuscular
integumentary- burns, frostbite, incisions
MSK
pulmonary
multisystem/other
Impairments of the integumentary system:
de-conditioning
claudication, tissue perfusion
skin lesions, adhesions, scars
sensory integrity
Wound healing chronology:
1.) inflammation
-longest stage
-peaks at 1-3 days
2.) proliferation
-peaks at 10 days
-overlaps with the inflammatory phase
-Also known as angiogenesis, this phase occurs when the wound is rebuilt with new tissue made of collagen and extracellular matrix.
3.) maturation- Also known as remodeling, this phase occurs when the wound fully closes and collagen is remodeled. This phase also involves scar tissue formation.
Hemostasis process:
1.) vessel injury
2.) vascular spasm with infiltration of platelets - smooth muscle contraction
3.) formation of the platelet plug - Fibrinogen converts to fibrin, the fibrin threads weave and stick together over the top of the platelet plug and hold the clump in place.
4.) the coagulation- fibrin filaments, red blood cells, and white blood cells the blood clot it formed ; fibrin strands secure the platelets and RBCs, effectively plugging the break (clot)
Infection control in the integumentary system:
- bacteria and other pathogens enter wound
- platelets from blood release blood clotting proteins at wound site
- Mast cells secrete factors that mediate vasodilation and vascular constriction. Delivery of blood, plasma, and cells to injured area increases
- Neutrophils secrete factors that kill and degrade pathogens
- Neutrophils and macrophages remove pathogens by phagocytosis
- Macrophages secrete hormones called cytokines that attract immune system cells to the site and activate cells involved in tissue repair
- inflammatory response contributes until the foreign material is eliminated and the wound is repaired
Inflammatory phase of wound healing:
o Requires a vascular & cellular response from living tissue
o Assists in controlling the bleeding & combating infection
o Sets the stage for further healing by signaling the cells for repair & regeneration
Characteristics: erythema, edema, tenderness, pain
Function: remove debris, start healing cascade and prepare wound for regeneration
Timeline: begins at injury and lasts a few days
-1: injured blood vessel walls allow transudate to leak into the interstitial space (local edema) –> helps with fluid leakage
-2: local blood vessels constrict for several minutes to reduce blood loss
-3: platelets aggregate at the injury site, become active and start sticking together
◦ Activated platelets release chemicals like cytokines (proteins), growth factors (for cell growth,
differentiation, metabolism), & chemotactic agents (attract cells for wound repair)
Cellular response in inflammatory phase of wound healing:
PMNs (polymorphonuclear neutrophils) - scavengers that kill bacteria and cleans wound
Macrophages - direct the repair process, assist with killing bacteria and cleaning wound, secretes growth factors
Mast cells - secretes enzymes and inflammatory mediators
Proliferative phase of wound healing
Timeline: begins around 48 hours, for weeks
Processes:
-angiogenesis (neovascularization)- capillaries form buds and grow
-granulation tissue formation- temporary latticework of vascularized CT to fill wound; eventually replaced by scar tissue; healthy, new tissue
-wound contraction- myofibroblasts drive this process, pulling wound edges together –> more for full thickness wounds, slower in circular wounds
-epithelialization - keratinocytes at wound margins and epidermal appendages begin to multiply and migrate –> closed barrier of wound
** unable to migrate over nonviable tissue
Epitheliaziation process of wound healing
-Epithelial cells migrate across the new tissue to form a barrier between the wound and the environment
-Basal epithelial cells at wound margin
–> multiply in horizontal direction
–> epithelial cells move toward and fill the edges of the wound and form a layer of cells
–> flatten (mobilize) and migrate into the open wound
-Basal cells behind margin undergo vertical growth (differentiation)
Remodeling phase of wound healing
-new collagen is formed
-old collagen broken down
-Collagen fibers from immature Type III to mature Type I
AND reorient along the lines of stress
-rosy, pink scar–> more pale with remodeling
-sensation, oils, sweat may be different after wound
-tissue never returns to same as it was before wound
-Timeline: Remodeling can continue for up to 2 years following wound closure, with the greatest change in the first 6-12 months
-Increase tensile strength over time, but never back to baseline (only 80%)
Primary intention wound closure:
clean, straight line, edges well approximated with sutures, rapid healing, usually best cosmetic outcome
Secondary intention wound closure:
larger wounds with tissue loss, edges not approximated, heals from the inside out, granulation tissue fills in the wound, longer healing time, larger scars
-wound left open and allowed to heal spontaneously/ fill
-contaminated/infected wounds
-increased scarring
**wound care PT more directly invovled
Tertiary intention wound closure:
delay is typically 3-5 days before injury is sutured, used to manage infected or unhealthy wounds, larger scar
-delayed primary closure
-good for contaminated/infected initially wounds