Back pain Flashcards

1
Q

ΔΔ back pain?

A

MECHANICAL:
• Disc herniation: can itself cause pain, or secondarily due to nerve root compression
• Trauma (can lead to sacroiliitis)
• Muscular pain

BONE
• Ankylosing spondylitis and other inflammatory arthropathies
• Osteoporotic vertebral crush.
• Paget’s disease of the bone.
• Primary or secondary bone cancer; often systemic symptoms too.

NEURO
• Cauda equina
• Spinal stenosis
• Nerve root compression

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2
Q

Hx: patient presents with bilateral, asymmetrical leg weakness, back pain, saddle (upper inner thigh)/perineal anaesthesia, bladder retention and incontinence?
+/- urinary overflow incontinence and constipation can also occur

Ex ↓reflexes

A

cauda equina syndrome
- lesions of the roots and nerves below the spinal cord, with LMN Sx

  • !!emergency decompression of the spinal canal w/n 48 hrs
  • nb that nerve root (radiculopathy) causes predominantly sensory Sx
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3
Q

Hx: patient presents with claudication characterised by back and leg pain (aching, heavy, weak) and lower extremity paraesthesia brought on by ambulation and relieved by sitting. Especially bad walking down stairs?

Ex: patient walks with a forward flexed gait

Cause? Ix? Tx? Complications?

A

spinal stenosis
ΔΔ in facet joint disease (aka facet syndrome) no leg claudication
ΔΔ cauda equina Sx or sciatica Sx

• cause - degeneration (spondylosis), esp facet joints, narrowing of spinal canal, usually lumbar, affects cord AND roots

Ix
• MRI + x-ray

Tx
• NSAIDs, physio, epidural steroid injections, severe: decompressive spinal surgery
• neuro deficit including sensory/motor loss in a quarter

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4
Q

Hx: patient presents with back pain, worse on lying/coughing, rapidly progressing to symmetrical sensory loss, then motor weakness (legs)
+/- ↑reflexes (may be absent if acute)
+/- ↑tone (spastic paraparesis)
+/- sphincter dysfunction (hesitancy, frequency, and later painless retention)
?

A

spinal cord compression

emergency!

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5
Q

Hx: 45 year old obese patient reports lumbosacral and buttock pain for 1 to 2 days after standing up in a strange position, stiffness, with muscle spasms, otherwise well?
Ex: benign physical examination
Ix? Tx?

A

mechanical back pain (muscle strain)

Ix - clinical diagnosis, exclude differentials (no X-rays for non-specific lower back pain <6wk)

Tx
• most patients recover within 3 months
• conservative (patient education, return to normal activity, temperature treatments - ice, heat)
• medical (oral NSAIDs, paracetamol, muscle relaxants, opioids if severe)
• physiotherapy if 4-6 weeks
• if chronic (>12 weeks) - CBT, acupuncture, injection therapies

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6
Q

Hx: patent presents with back pain of sudden onset after lifting a heavy object
• which worsens with standing or sitting, or motion, and relieved by rest or lying down
• pain refers to paraspinal muscles, bum, and back of thighs. +/- radicular (dermatomal) pain or in the groin or flank
+/- NO sphincter dysfunction or saddle anaesthesia?

Ex: positive straight-leg raise, pain worse on spine flexion

Ix? Tx?

A

herniated disc/degenerative disc disease

  • lumbar spinal X-ray and MRI
  • analgesia, physio, injection or decompression if needed
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7
Q

Hx: patient presents with 6 months history of lumbar back pain, worse with activity, recurrence of previous episode a year previous? Tx?

yellow flags?

A

chronic back pain

  • educate, encourage activity
  • pain clinic referral
  • optimal analgesia, amitriptyline
  • alternative therapies
  • physio
  • facet joint blocks
  • believe activity harmful
  • low mood
  • sickness behaviour
  • work dissatisfaction
  • seeking compensation
  • not engaged in treatment
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8
Q

Hx: 75 year old lady patient presents with back pain at rest and at night following trauma to back, PMHx distal radius fracture, on long term steroids?

Ex: tenderness to palpation over the midline
• normal neurological ex

A

osteoporotic compression fracture

Ix
• plain x-ray: wedging of the vertebral bodies, typically anteriorly
• exclude malignancy or infection!
Tx
• pain relief
• brace
• walking aids
• surgery if terrible
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9
Q

Hx: patient presents with severe 8/10 back pain, fever, weight loss, pain particularly at rest and at night, on chemo with PMHx DM?

Ex: malaise, fever, local erythema and swelling, localised tenderness (esp on percussion), no neuro Sx

Ix? Tx?

A

infection (discitis, osteomyelitis)

Ix
• FBC, (↑ neutrophils)
• ESR, CRP
• blood cultures: mostly S. aureus and Strep
• x-rays: may demonstrate end-plate/vertebral body destruction
• MRI: increased signal intensity

Tx
• 4 wks IV Abx

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10
Q

Hx : 56 year old pt presents with back pain at night and at rest, difficulty urinating for 8 months, fevers/chills, weight loss, and malaise +/- neuro Sx?

Ex: local tenderness

Ix? Tx?

A

malignancy (most commonly 2’ to prostate CA)

Ix
• x-ray, MRI, CT
• chemo, radio, etc

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11
Q

Hx: 30 year old man presents with diffuse non-specific pain over months, goes to buttocks bilaterally, is present at night, worse in the morning with stiffness, fatigue, weight loss?
Pain improves after physical activity.

Ex: stiffness of spine with kyphosis, limited ROM of lower spine, tenderness on palpation, rash (psoriasis) +/- uveitis

Ix? Tx?

A

ankylosing spondylitis
• “seronegative spondyloarthropathy” - psoriatic arthritis, enteropathic arthritis, and reactive arthritis, HLA-B27 associated

Ix
• x-ray: erosion of sacroiliac joint and later narrowing and fusion (bamboo spine)
• MRI
• FBC (↑wbc)
• CRP, ESR
• DNA testing: HLA B27 (may be -ve)

Tx
• NSAIDs
• Physiotherapy
• Tumour necrosis factor (TNF-alpha inhibitors)

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12
Q

Hx: 47 year old female patient presents with back pain, knee pain, fever, weight loss, and fatigue?

Ex: rash, signs of malabsorption, joint tenderness, joint effusion and swelling
+/- uveitis, conjunctivitis
+/- lymphadenopathy, wheeze

A

connective tissue disease (eg, RA)

  • FBC
  • serum Ab - RF (RA)
  • ESR (RA)
  • CXR: normal/mediastinal lymphadenopathy/ILD, effision
  • plain x-ray of spine:may be evidence of rheumatoid arthritis
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13
Q

Hx: older patient with sudden onset of back pain, and abdo pain, +/- collapse?

Ex: pulsatile abdominal mass, hypotension or hypertension, tachycardia

A

AAA

Ix
• US/CT if stable
• surgery

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14
Q

Hx: sudden epigastric pain, radiates to back, relieved by sitting forwards, associated with N, V, Hx alcohol or GS?

Ex: tachycardia, fever, jaundice, tenderness/guarding of abdomen, +/- bruising

A

pancreatitis

  • serum lipase
  • amylase
  • US
  • ERCP
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15
Q

Hx: back and flank pain, with dysuria, frequency, and hesitancy, fever, chills, fatigue?

Ex: flank or costovertebral tenderness

A

pyelonephritis

Ix
• urinalysis, MC+S
• US

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16
Q

Hx: patient has back pain, with severe, acute 10/10 flank pain, may radiate to groin, N, V, on antacids for reflux?

Ex: flank or costovertebral angle tenderness +/- macroscopic haematuria

A

renal colic

Ix:
• urinalysis
• non-contrast CT

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17
Q

Hx: patient has back pain and epigastric, burning pain, usually after meals, +/- relieved by antacids +/- haematemesis or melaena

Ex: epigastric tenderness, +/- melaena on PR

A

peptic ulcer disease

Ix:
• upper gastrointestinal endoscopy

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18
Q

which cancers commonly metastasise to the spine?

A
• prostate (commonest)
• breast
• lung
• kidney
(paired organs)
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19
Q

what are the seronegative spondyloarthropathies?

A
  • ank spondylitis (back pain)
  • psoriatic arthritis (rash)
  • enteropathic arthritis (IBD)
  • reactive arthritis (can’t wee, see, climb a tree)

all HLA-B27 associated

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20
Q

when to x-ray?

A
  • recent significant trauma (at any age)
  • osteoporosis
  • age >70 years (MRI best though)
21
Q

Hx: 65 year old male patient presents with deep back pain that doesn’t go away at night, fatigue, two day history of being unable to wee?

A

multiple myeloma

Ix
• serum free light-chain assay
• serum / urine protein electrophoresis
• FBC (anaemia), CRP
• LDH
• urea, creatinine (AKI)
• Ca++ (↑↑), bone profile
• BM aspirate, biopsy
• skeletal survey
• whole-body CT, MRI, PET

Tx
• chemo
• BM transplant

22
Q

main thing differentiating cord compression from cauda equina?

A
  • cord compression = UMN and LMN Sx

* cauda equina = peripheral nerve compression therefore LMN Sx ONLY

23
Q

UMN Sx vs LMN?

A
UMN
• (early: ↓tone + reflexes)
• established:
normal bulk
↑tone
↑reflexes (Babinski - upgoing plantar reflex, ankle clonus)
↓power
no fasciculations
LMN
• established:
↓bulk
↓tone
↓reflexes
↓power
fasciculations
wasting
24
Q

a known cancer patient presenting with worsening back pain or impaired mobility/sensation?

A

be suspicious of spinal cord compression!

25
Q

Tx acute spinal cord compression?

A
  • 16mg dexamethasone PO/IV loading dose then daily, + PPI (high dose!)
  • alert neurosurgery
  • MRI whole spine
  • do PR exam
  • neurosurgery/radiotherapy/chemotherapy
26
Q

where does the spinal cord normally compress?

A

thoracic

27
Q

ΔΔ causes spinal cord compression?

A
  • mets: breast, lung, prostate, myeloma, renal cell
  • infection: discitis, epidural abscess, TB• trauma
  • slipped disc
  • vertebral crush # due to OP
  • Ewing’s sarcoma of the spine
  • primary CNS cancer (ependymoma, meningioma, glioma)
28
Q

ΔΔ spinal stenosis from cord compression?

A

• both can compress cord AND root

29
Q

ΔΔ spinal stenosis from cord compression from cauda equina from lumbar radiculopathy (sciatica)?

A
  • spinal stenosis - leg claudication, heavy aching legs, nerve AND root
  • cord compression - rapidly progressives to symmetrical sensory and motor problems in legs, with UMN Sx as nerve NOT root (↑reflexes, ↑tone, sphincter dysfunction)
  • cauda equina - saddle anaesthesia, incontinence/retention, bilateral weakness, ONLY roots
  • sciatica - UNILATERAL sharp leg pain to foot, ONLY roots
30
Q

conus medullaris syndrome vs cauda equina?

A

conus medullaris lesions are tapered end of the spinal cord, at level L1-2, mixed UMN/LMN presentation (↑knee but ↓others), erectile dysfunction

cauda equina has less back pain but more radicular pain, less erectile dysfunction, later urinary retention
less fasciculations, more atrophy

31
Q

what is a radiculopathy?

A

nerve root compression:

ΔΔ
Disc degeneration and herniation.
Spondylosis (vertebral degeneration) and spondylolisthesis (vertebral displacement).
Trauma

32
Q

Hx: patient has sharp, stabbing, electrical UNILATERAL buttock and leg pain radiating to foot/toes, weakness in one myotome?

Ex: straight leg raise reproduces pain, +/- numbness and paresthesia in a dermatomal distribution
+/- ↓reflexes and muscle weakness

A

lumbar radiculopathy
(causing) 90 percent of sciatica (L4-S3)

causes radiculopathy, again:
ΔΔ 
Disc degeneration and herniation.
Spondylosis (vertebral degeneration) and spondylolisthesis (vertebral displacement).
Trauma
33
Q

which nerve roots affected in sciatica?

A

L4-S3

liverpool 4, us 3

34
Q

Tx lumbar radiculopathy (causing 90 percent of sciatica)?

A
  • continue ADLs, patient education, physiotherapy, psychological support, usually settles within 4-6 weeks
  • analgesia: start simple (paracetamol and/or NSAIDs), then consider weak opioids or neuropathic analgesia (amitriptyline, gabapentin)

• refractory sciatica: consider epidural steroid or local anaesthetic injections if severe, acute, and persists >1-2 weeks
- consider MRI and spinal decompression surgery if persists >6-8 weeks

35
Q

Back pain red flags?

“CT BACK PAIN”

A

actually, get an MRI!!!

  • (constitutional) fever, fatigue, weight loss, night sweats
  • thoracic pain
  • bowel or bladder symptoms: cauda equina
  • anaesthesia in saddle area: cauda equina
  • co-morbidities – cancer, HIV, or steroid use
  • (K)claudication: spinal stenosis
  • progressive/constant pain
  • age <20 years or >55 years at onset
  • insomnia from pain (noctural/waking at night)
  • neurological Sx (incl sciatica), bilateral leg pain
36
Q

which nerve roots does the straight leg raise test?

A

L4, L5, S1

+ve if causes pain below the knee

37
Q

what additional Ex to do with back ex?

A

PR (perianal tone and sensation)

38
Q

Lasegue’s sign? what is the main cause?

A

foot dorsiflexion increases pain in the straight leg raise
(irritation of sciatic nerve)
(main cause lumbar disc prolapse)

39
Q

femoral stretch test - what is it? what does it test?

A
  • pain in front of thigh on lifting the hip into extension with the patient lying face down, knee flexed
  • tests L2-L4
40
Q

commonest causes by age:
• 15-30 yrs
• 30 - 50 yrs
• > 50 yrs

A
  • prolapsed disc, trauma, ank spond
  • degenerative, prolapsed disc, CA
  • degenerative, OP vertebral collapse, Paget’s, CA, myeloma, spinal stenosis
41
Q

what is spondylolisthesis?

A

forward shift of one vertebra over another which is congenital or due to trauma (likeliest in 15-30 years)

42
Q

Ix back pain?

A

only if suspect a specific cause/red flags

BEDSIDE
• urine sample (electrophoresis)

BLOODS
• FBC, ESR, CRP (myeloma, infection, CA)
• U+E, ALP (Paget’s)
• PSA (CA)

IMAGING
• XR (bony abnormalities, #)
• MRI (disc prolapse, cord compression, CA, infection, inflammation - sacroiliitis)

43
Q

neurosurgical emergencies + Sx for each? Causes?

A

• CAUDA EQUINA

  • alternating/bilateral root pain in legs
  • saddle anaesthesia (perianal)
  • loss of anal tone on PR
  • bladder +/- bowel incontinence

• CORD COMPRESSION

  • bilateral pain
  • LMN Sx at level of compression (↓tone, ↓reflexes, fasciculation)
  • UMN Sx and sensory loss below
  • sphincter disturbance

• Causes

  • bony mets (missing pedicle on XR)
  • large disc protrusion
  • myeloma
  • cord/paraspinal tumour
  • TB
  • abscess
44
Q
  • pain across upper thigh
  • weak hip flexion and adduction

nerve root affected?

A

L2

45
Q
  • pain across lower thigh
  • weak hip adduction, knee extension
  • knee jerk affected

nerve root affected?

A

L3

46
Q
  • pain across knee to medial malleolus
  • weak knee extension, foot inversion and dorsiflexion
  • knee jerk affected

nerve root affected?

A

L4

47
Q
  • pain across lateral shin to dorsum of foot and great toe
  • weak hip extension/abduction, knee flexion, foot and great toe dorsiflexion
  • great toe jerk affected

nerve root affected?

A

L5

48
Q
  • pain across posterior calf to lateral foot and little toe
  • weak knee flexion, foot and toe plantar flexion, foot eversion
  • ankle jerk affected

nerve root affected?

A

S1