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RDS Test 4 > B8.070 Drugs Affecting Sexual Function and Fertility > Flashcards

B8.070 Drugs Affecting Sexual Function and Fertility Flashcards

1
Q

drug: estrogens/ progestins
indication: BC

A

effect on fertility:

women: impair LH/FSH surge > anovulation
men: decreased sperm number

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2
Q

drug: NSAIDs
indication: pain, inflammation

A

effect on fertility:

women: interfere with ovulation (follicular rupture)

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3
Q

drug: glucocorticoids
indication: immunosuppression, inflammation

A

effect on fertility:

women: interfere with LH, FSH

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4
Q

drug: antipsychotics
indication: schizophrenia

A

effect on fertility:

women: D2 antagonist > increased prolactin > menstrual irregularity
men: ED, same as women

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5
Q

drug: opioids
indication: pain, etc.

A

effect on fertility:

women: decreases LH > menstrual irregularity
men: decreases LH > decreased T > decreased sperm production and quality

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6
Q

drug: chemo/radiation
indication: cancer

A

effect on fertility:

women: disrupted menstrual cycle/amenorrhea, primary ovarian failure (damage to ovaries)
men: decreased sperm production (can be permanent)

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7
Q

drug: anticonvulsants
indication: epilepsy, bipolar

A

effect on fertility:
women (valproate): disrupt ovulation
men (phenytoin, carbamazepine, valproate): decreased sperm number and motility, abnormal sperm morphology, decreased testicular volume, possible effect on HPG axis

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8
Q

drug: spironolactone
indication: diuretic, antiandrogen

A

effect on fertility:

women: blocks 17 a-hydroxylase > decreased fertility

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9
Q

drug: cannabinoids
indication: recreational/ medicinal

A

effect on fertility:

women: THC in repro tract inhibits sperm motility, may affect oviductal embryo transport, implantation
men: decreased sperm production and function, decreased T > decreased libido

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10
Q

drug: diethylstibestrol (DES)
indication: in utero exposure

A

effect on fertility:
abnormalities of the uterus and cervix, variable menstrual cycles
men: testicular hypoplasia, decreased number and motility, abnormal sperm morphology

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11
Q

drug: SSRIs
indication: depression

A

effect on fertility:

women: decreased libido, anorgasmia
men: ED, impaired ejaculation, increased sperm DNA fragmentation, decreased sperm motility

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12
Q

drug: T/ anabolic steroids
indication: replacement, catabolism, infertility

A

effect on fertility:

testicular atrophy, decreased T production, decreased sperm production

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13
Q

drug: Ca2+ channel blockers
indication: HTN

A

effect on fertility:

decreased sperm motility, nifedipine blocks acrosomal reaction

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14
Q

drug: antiandrogens (spironolactone, flutamide, cyproterone)
indication: prostate cancer

A

effect on fertility:

decreased sperm production, decreased semen volume

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15
Q

drug: alcohol (>14/wk)
indication: recreational

A

effect on fertility:

decreased T production, increased T metabolism > decreased sperm production

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16
Q

drug: tobacco
indication: recreational

A

effect on fertility:

decreased sperm production and motility

17
Q

drug: 5a-reductase inhibitors
indication: prostate cancer, hair loss

A

effect on fertility:

decreased DHT > decreased semen volume and total number of sperm

18
Q

drug: a blockers
indication: BPH

A

effect on fertility:

anterograde, anejaculation, or decreased ejaculation volume, decreased sperm production and motility

19
Q

drug: ketoconazole (oral)
indication: fungal infections

A

effect on fertility:

inhibits 17a-hydroxylase > decreased T production, decreased sperm production

20
Q

drug: antiretrovirals (HAART, saquinavir)
indication: HIV

A

effect on fertility:

decreased sperm number and motility, abnormal sperm morphology, decreased ejaculate volume

21
Q

drug: sulfasalazine
indication: anti-inflammatory, Crohn’s, RA

A

effect on fertility:

anti folate and anti-PG activity > decreased sperm number and motility

22
Q

drug: cimetidine
indication: H2 blocker, GERD

A

effect on fertility:
decreased sperm number
may have anti-androgenic effects

23
Q

drug: colchicine
indication: gout

A

effect on fertility:

decreased sperm number

24
Q

drug: antibiotics
indication: infection

A

effect on fertility:

decreased sperm number

25
Q

drug: antimalarials
indication: malaria

A

effect on fertility:

decreased T production

26
Q

drug: cocaine
indication: recreational

A

effect on fertility:

decreased sperm number

27
Q

drug: heavy metals
indication: toxins

A

effect on fertility:
decrease sperm number. motility, lifespan
Cr causes testicular atrophy

RDS Test 4 (17 decks)

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