B6.3 - 2 Flashcards

1
Q

What is a risk factor?

A
  • things that increase a person’s chance of getting that disease
  • often related to person’s lifestyle or substance in environment or genetic predisposition for a disease (e.g inheriting particular mutated alleles increases your risk of developing coronary heart disease)
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2
Q

What makes you more susceptible to cancer?

A
  • inheriting faulty genes
  • the genes alone don’t mean you will get cancer but the chance is increase if you have other risk factors too such as poor diet, high alcohol consumption and smoking
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3
Q

How are risk factors identified by scientists?

A
  • looking for correlations for data birth it doesn’t always equal cause
  • sometimes a link factor is linked to another which usually causes the disease
  • e.g lack of exercise and high fat diet are linked to increase chance of CVD but they can’t cause it directly but instead, the high blood pressure and high ‘bad’ cholesterol levels that can actually cause it
  • e.g smoking can cause lung cancer and lung disease
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4
Q

How does exercise effect the risk of non-communicable diseases?

A
  • exercise increase amount of energy used by body and decrease the amount of stored body fat
  • build muscle which boosts metabolic rate so people who exercise are less likely to suffer from health problems such as obesity and CVD
  • lack of exercise increases risk of CVD and increases blood pressure
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5
Q

How does obesity effect the risk of non-communicable diseases?

A
  • eating too much = obesity (more than 20% of max recommended body mass)
  • can lead to type 2 diabetes, CVD and high BP
  • too much saturated fat = increase blood cholesterol level and cholesterol is an essential lipid that body produces to function properly
  • too much cholesterol = bad/LDL cholesterol can cause fatty deposits in arteries = leads to coronary heat disease
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6
Q

How does malnutrition effect the risk of non-communicable diseases?

A
  • eating too little = suffer from lack of food
  • malnutrition (badly out of balance diets) can cause slow growth (in kids), fatigue, poor resistance to infection and irregular periods (in women )
  • deficiency disease are caused by lad, of vitamins or minerals e.g lack of vitamin C = scurvy (cause by problems with skin, joints and gum)
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7
Q

How does alcohol lead to non-communicable diseases?

A
  • is poisonous as it’s broken down by enzymes in the liver and some of the products are to toxic
  • contains alcohol which effects the nervous system
  • depressant so slows down the body’s reactions
  • recommenced 2 units/day for women
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8
Q

What are the short term effects of alcohol?

A
  • blurred vision
  • loss of balance
  • slowed reaction times
  • change in behaviour
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9
Q

What are the long term effects of alcohol?

A
  • healthy liver is replaced with fat/fibrous tissue so liver is less effective at removing body toxins, which can cause death of liver cells, forming scar tissue that stops blood from reaching liver = cirrhosis
  • can increase blood pressure = lead to CVD (heart disease)
  • many cancers (mouth, throat, bowel and liver) linked to alcohol as toxic products damage DNA and a use cells to divide faster than normal
  • stomach ulcers
  • brain damage
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10
Q

How does alcohol smoking to non-communicable diseases?

A
  • tobacco has 4,000 chem out of which 43 are known carcinogens (cancer causing) and 400 other toxins
  • burning cigarettes produce nicotine (makes it addictive) and also produces CO, tar and particulates
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11
Q

What are the affects of tar, CO, particulates and nicotine?

A
  • tar collects in the lungs (carcinogens)
  • nicotine = makes heart beat faster and narrows blood vessels (effects the nervous system)
  • CO = attaches to haemoglobin so less O2 is transported making the heart work harder
  • particulates = small pieces of solid that are engulfed by WBC and release an enzyme which weakens alveoli walls leading to emphysema
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12
Q

What are the long term affects of smoking?

A
  • CVD - CO reduces O2 capacity of blood and if cardiac muscle doesn’t get enough O2 = heart attack and nicotine increases heart rate so higher blood pressure = more risk of CVD
  • lung throat, mouth and oesophageal cancer-carcinogens from tar make mutations in DNA more likely which lead to uncontrolled cell division
  • lung diseases (chronic bronchitis) - cigarette smoke causes inflammation of lining to bronchi and bronchioles (tubes in lungs) which = permanent damage (symptoms = persist cough and breathing problems)
  • smoking when pregnant = health problems for unborn baby
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13
Q

How do lifestyle factors cause different trends of non communicable diseases globally?

A
  • non communicable disease = more common in developed countries (higher income) but now more common in developing
  • lack of exercise and higher alcohol consumption are associated with higher income
  • smoking varies b/w countries but smoke related death = poorer countries
  • developed and developing = obesity is associated with higher incomes as people can afford lots of high fat foods but now also associated with poor as people eat cheaper, less healthy foods
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14
Q

How do lifestyle factors cause different trends of non communicable diseases nationally?

A
  • non communicable disease = biggest cause of death in UK
  • people from deprived areas = more likely to smoke, have poor diet and not take part in physical activity than those better off financially
  • so incidence of heart disease, type 2 diabetes, obesity and cancers are higher in those areas
  • people from deprived areas = also suffer from alcohol- related disorders
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15
Q

How do lifestyle factors cause different trends of non communicable diseases locally?

A
  • individual lifestyle choices affect the incidence on non communicable disease at local level
  • if you choose to smoke, drink and not take part in exercise or have poor diet, the risk increases
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16
Q

What is CVD?

A
  • Cardiovascular disease = disease of the heart and blood vessels
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17
Q

What is atherosclerosis?

A
  • hardening of the arteries and the arteries becoming narrow
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18
Q

How does CVD happen?

A
  • high BP and lots of LDL cholesterol can lead to build up of fatty deposits inside arteries, narrowing them and over time they harden, forming atheromas
  • coronary heart disease is when the coronary arteries have lots of atheromas in them , which restricts blood flow to the heart
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19
Q

How can CVD cause a heart attack or a stroke?

A
  • when the atheromas break off or they damage the blood vessel, it causes a blood clot (thrombosis)
  • complete blockage of one of the coronary arteries (arteries taking blood back to heart to supply with glucose and oxygen) by atheromas/ blood clots lead to a heart attack when part of cardiac muscle is deprived off oxygen
  • if the blockage occurs in artery supplying the brain =causes a stroke
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20
Q

What are the risk factors of CVD?

A
  • too much salt as more water is being absorbed back into blood after filtration in the kidney which creates higher blood pressure
  • diet has a lot of saturated fats so cholesterol is deposited in the artery wall which results in narrower blood vessels which restrict blood flow and increase blood pressure (high levels of fat are found in butter and red meat)
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21
Q

How does exercise affect CVD?

A
  • exercise leads to lower body mass as less food consumed is stored as fat = low risk of CVD diseases
  • healthier joints and low risk of arthritis
  • greater muscle tissue (including stronger heart)
  • low cholesterol levels in blood
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22
Q

How can lifestyle changes treat CVD?

A
  • reduces risk by exercising regularly
  • reduce alcohol consumption
  • stop smoking
  • eat a healthy diet which is low in saturated fat and less processed foods
  • these changes can also aid along with treatment
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23
Q

What drugs/ medication is used to control effects of CVD?

A
  • stains
  • anti platelets/ anti couaglants
  • nitrates/ antihypertensives
  • beta blockers
24
Q

What is the function and side effects of stains in treating CVD

A
  • reduce the amount of cholesterol in the bloodstream which slows the rate of fatty deposits forming, reducing risk
  • can cause aching muscles, upset stomach or maybe even kidney failure, liver damage and memory problems
25
Q

What is the function and side effects of anti platelets/ anti couaglants in treating CVD

A
  • it lowers the stickiness of platelets so blood clots are less likely to form
  • can cause internal bleeding or too much in an accident
26
Q

What is the function and side effects of nitrates/ antihypertensives in treating CVD?

A
  • some reduce blood pressure by widen blood cells, or decreasing strength of the heart beat or reduce the blood volume
  • they widen blood vessels by relaxing blood vessel walls and allowing to blood to flow at lower pressure
  • this reduces risk of atheromas and blood clots
  • May cause headaches, fainting or dizziness
27
Q

What is the function and side effects of beat blockers in treating CVD?

A
  • blocks the effects of adrenaline so heart rate is slower and there is a better blood flow
  • May cause dizziness and tiredness
28
Q

What surgeries are used to treat CVD?

A
  • valve replacement
  • angioplasty
  • coronary bypass
  • heart transplant
29
Q

How does valve replacement treat CVD?

A
  • faulty valves let blood flow backwards which can lead to heart failure as there not enough oxygenated blood reaches the heart muscle
30
Q

How does angioplasty treat CVD?

A
  • insert a stent ( a tube) into a partial.y blocked artery to widen them
  • they keep them open ensuring blood can pass through to the cardia muscle and lower risk of heart attack
  • but over time the arteries can narrow again as stents can irritate the artery and make scar tissue grow
  • patient also has to take drugs to stop blood clotting on the stent
31
Q

How does coronary bypass treat CVD?

A
  • if a blood vessel is blocked then a piece of healthy vessel taken from somewhere else is used to bypass the blocked coronary arteries
32
Q

How does heart transplant treat CVD?

A
  • whole heart can be replaced with a donor heart
  • however new heart doesn’t always start pumping properly and may also be rejected from the body as the immune system recognises it as ‘foreign’
  • drugs are given to prevent this from happening but can have side effect = making you more vulnerable to infections
  • overall complicated and takes a long time for a donor
33
Q

What are the risks with heart surgeries?

A
  • it’s a major procedure and there is risk of bleeding, clots and infection
34
Q

How do transplants work?

A
  • organs have been matched to the recipient otherwise the body rejects it as it recognises it as foreign tissue and the immune system destroys it
35
Q

How do we reduce the risk of rejection in transplants?

A
  • tissue matching = ensures the donor organ is a similar tissue type to recipient
  • immunosuppressant drugs used and given to recipient to reduce the effect of the immune system
36
Q

Why are there concerns transplanting from embryonic or donor stem cells?

A
  • rejection as immune system recognises it as foreign
  • but if patient needs a stem cell transplant and their own adult stem cells can be used, it’s thought to be less risk of a rejection
38
Q

What are stem cells?

A
  • undifferentiated/ unspecialised cells that are normally taken from embryo (embryonic) so can differentiate into any type of cell
  • adult stem cells are also used in a few causes
  • fertility treatments are a source of stem cells (IVF)
39
Q

How is stem cells used in Leukaemia?

A
  • Leukaemia is a cancer of the blood or bone marrow
  • bone marrow transplants can be used to replace faulty bone marrow in patients suffering from it
  • bone marrow has stem cells that can specialise to form any time of blood cell (adult stem cells used to successfully treat it)
  • stem cells in the transplanted bone marrow produce healthy blood cells
40
Q

How can scientists get very early human embryos?

A
  • In IVF
  • egg cells are fertilised by sperm cells outside the womb
  • once embryos are approx 4 to 4 days old the stem cells are removed from them and the rest of the embryo is destroyed
41
Q

How could stem cells be used to reverse damage caused by diseases?

A
  • replace faulty cells so you can make beating heart muscle cells from people with heart disease
  • insulin producing cells for people with diabetes
  • nerve cells for people paralysed by spinal injuries
  • brain cells to treat Parkinson’s Disease
  • generate heart valves for valve replacement
  • treating arthritis = rebuilding bone and cartilage (adult)
  • red blood cells made to treat Leukaemia (adult)
42
Q

How do you get cultures of one specific type of cell?

A
  • researchers try to control the differentiation of stem cells by changing the environment they’re growing in
  • so far its bit of a hit and miss so more research is needed
43
Q

What are the concerns with stem cell research over all?

A
  • possible rejection of foreign materials in the body
  • possible long term effects (might be increased risk of cancer)
  • unethical to use embryos
44
Q

Why are the for and against of using human embryos in stem cell research?

A

Against:
- since it’s one potential life
- campaigners also want to ban use of fertility clinic embryos
For:
- others think that curing patients who already exist and suffering is more important that rights of embryos
- unwanted embryos from fertility clinics are used for research so if they weren’t used by scientists they would probably be destroyed anyway

45
Q

What laws are made on stem cells regarding the issue of some people being against it?

A
  • controversial topic so gov made laws about how they should be used in research and medicine
  • around the world now there are ‘stocks’ of stem cells that scientists can use for their research. Some countries (USA) won’t fund research to make new stem cell ‘stocks’ but in the UK it’s allowed as long as it follows strict guidelines
47
Q

What could stem cells be used for?

A
  • test new drugs for effectiveness and safety

- reverse damage caused by diseases

48
Q

What is gene therapy and give an example of where it can be used

A
  • placement of a fully functioning allele into a cell containing a faulty allele for the same gene
  • could be used for cystic fibrosis (cause by a faulty CFTR gene) by replacing the faulty with normal CFTR gene
49
Q

How does gene therapy work?

A
  • restriction enzymes cut the normal version of a gene from a healthy person
  • then produce many copies of that normal allele
  • insert copies into the cells of a person with genetic disorder using a virus as a vector (carries the allele)
50
Q

What are the problems with inserting the healthy allele into the target cell?

A
  • healthy alleles may not go into every target cell we need them to
  • healthy allele may join chromosomes in a random place so don’t work properly
  • treatment is short lived as the cells are naturally replaced by the body
51
Q

What is the human genome project?

A
  • HGP was a 13 year long project to sequence and identify all the genes in human DNA
52
Q

What were the benefits of the HGP?

A
  • locating genes that may to linked to inherited diseases
  • develop drugs that directly target disease causing genes or their proteins
  • develop new gene therapy treatments
  • develop personalised medicine (target/precision medicine) = targeted medicine have greater success rates and fewer side effects
53
Q

How does genome research allow us to predict and prevent diseases?

A
  • common diseases (cancer/heart disease) are caused by interaction of many genes and lifestyle factors so if doctors knew what genes predisposed ppl to what diseases = we could all get individually tailored advice on the best diet and lifestyle to avoid our problem
  • inheriting particular genes = increases risk of getting cancer so if a person knows you have those genes, it may help them make choices to reduce the risk
  • doctors could also check regularly to see what diseases we’re susceptible to
54
Q

How does genome research allow us to develop new and better medicine ?

A
  • scientists used information from genes that caused diseases to develop new medicine
  • new medicines are able to specifically target the diseases at the molecular level
55
Q

How does genome research highlighted common genetic variations in people?

A
  • it is known that some of these variations makes some drugs less effective
  • e.g some asthma drugs are less effective for people with a particular mutation
  • scientists can use this knowledge to design new drugs that are tailored to people with these variations
56
Q

What are the risks of using gene technology in medicine?

A
  • increased stress for individuals
  • gene-ism as people with genetic problems don’t have children
  • discrimination by employers and insurers
  • unfair health system = creating specific drugs for diff ppl with increase cost for company =only wealthier can afford new drugs
  • practical risks = may harm that doing more good as we don’t know what effect there may be in further generation
57
Q

How does gene technology cause increased stress, gene-ism and practical risks?

A
  • increased stress = if someone knew they were more susceptible to brain disease they could panic every time they get a headache (even if they never got the disease)
  • gene-ism = people with genetic problems could come under pressure to not have children
  • practical risks = may harm that doing more good as we don’t know what effect there may be in further generation
58
Q

How does gene technology cause discrimination and unfair health system?

A
  • discrimination by employers and insurers = like insurance would become expensive or impossible to get if you have genetic likelihood of a serious disease and employers may discriminate against those who are genetically likely to get disease
  • unfair health system = creating specific drugs for diff ppl with increase cost for company so new drugs could be more expensive which could lead to two-tier health service = only wealthier can afford new
    drugs