B6 - Cell division Flashcards
1
Q
What are the phases of the cell cycle?
A
- interphase
- mitotic (division) phase
2
Q
What takes place during interphase?
A
- DNA replication/checked
- protein synthesis
- mitochondria grow/divide
- chloroplasts grow/divide
- metabolic processes occur
3
Q
What are the three stages of interphase?
A
- G1= first growth phase
- proteins are synthesised
- organelles replicate
- mRNA made
- cell increases in size
- S = synthesis phase
- DNA is replicated in nucleus (produces chromatids)
- G2 = second growth phase
- cell continues to increase in size
- energy stores increased
- duplicated DNA is checked for errors
4
Q
What are the three checkpoints of the cell cycle?
A
- G1 checkpoint = end of G1
- cell size
- nutrients
- growth factors
- DNA damage
- if it does not meet the requirements, it enters the G0 phase (resting state)
- G2 checkpoint = end of G2
- cell size
- DNA replication
- DNA damage
- spindle assembly = metaphase checkpoint
- all chromosomes should be attached to spindles/aligned
- mitosis cannot proceed until this checkpoint is passed
5
Q
What is G0?
A
- phase where a cell leaves the cycle (temporarily/permanently)
- differentiation = specialised cells are unable to divide (will not enter cell cycle again)
- damaged DNA = unable to divide and enters period of permanent arrest
- number of (senescent) cells increases as you age, which has been linked to diseases such as cancer/arthritis
- lymphocytes are able to go back into cell cycle in an immune response
6
Q
What is the mitotic phase?
A
- mitosis = the division of the nucleus
- cytokinesis = cytoplasm divides and two cells are produced
7
Q
Why is mitosis important?
A
- growth
- tissue repair
- asexual reproduction in plants, animals, fungi
- replacement of old cells
8
Q
What are the main stages of mitosis?
A
- prophase
- metaphase
- anaphase
- telophase
9
Q
What happens during prophase?
A
- chromatins condense to form chromosomes (not visible during interphase)
- nucleolus disappears and nuclear envelope breaks down
- protein microtubules form spindle fibres, linking the poles of the cell
- centrioles (protein bundle) move to opposite poles
- spindle fibres attach to centromeres and begin to move the chromosomes
10
Q
What happens during metaphase?
A
- the spindle fibres move the chromosomes to the centre of the cell
- forms a metaphase plate and is held in position
11
Q
What happens during anaphase?
A
- the centromeres divide, separating each pair of sister chromatids
- the spindle fibres shorten and pull the chromatids to opposite sides of the cell
12
Q
What happens during telophase?
A
- the chromatids are now called chromosomes
- nuclear envelope reforms around them
- chromosomes uncoil and nucleolus forms
- nuclei are genetically identical to each other
13
Q
What is cytokinesis?
A
- the division of the cytoplasm
14
Q
What happens during cytokinesis in animal cells?
A
- cleavage furrow forms around centre of cell
- cytoskeleton pulls the cell membrane inwards to fuse around the middle
- forms two new cells
15
Q
What happens during cytokinesis in plant cells?
A
- vesicles from Golgi apparatus assemble where the metaphase plate was formed (centre of cell)
- vesicles/cell membrane fuse together and forms two new cells
- new sections of cell wall form along new cell membrane
16
Q
What is meiosis?
A
- the formation of gametes (haploid)
- a gamete contains half the chromosome of parent cell
- fertilised egg = zygote
- reduction division
17
Q
Why is meiosis important?
A
- produces genetically unique daughter cells
- crossing over
- independent assortment
18
Q
What are homologous chromosomes?
A
- matching sets of chromosomes (in nucleus)
- diploid
- each chromosome in the pair has the same genes at the same position
19
Q
What are the stages of meiosis?
A
- meiosis I (first division - reduction)
- meiosis II (similar to mitosis