B5.081 Prework 1: Renal Tumors Flashcards
most common kidney neoplasms
- RCC (3 subtypes)
- wilms tumor
- urothelial tumors of renal pelvis
epidemiology of RCC
30,000 new cases/year in US
typically older patients (60s-70s)
2:1 M:F
where does RCC arise from
arise from renal tubular epithelium
risks factors for RCC
tobacco** obesity, HTN, asbestos, petroleum, heavy metals renal failure (long term dialysis) tuberous sclerosis vHL
rare familial variants of RCC
autosomal dominant
von Hippel Lindau (vHL)
hereditary papillary carcinoma
von Hippel Lindau
RCC occurs in 2/3 of patients with vHL
often bilateral
loss of vHL tumor suppressor gene
hereditary papillary carcinoma
multiple bilateral tumors
mutated MET proto-oncogene
most common type of RCC
clear cell carcinoma
description of clear cell carcinoma
70-80% of renal cell cancers
proximal tubule origin
clear or granular cytoplasm
95% are sporadic
gross appearance of clear cell carcinoma
well circumscribed, tan mass
arises in parenchyma
histo appearance of clear cell carcinoma
multiple small cells with clear cytoplasm
blood vessels scattered throughout
cytogenetics associated with clear cell carcinoma
loss of sequences on short arm of chromosome 3 OR unbalanced translocation with loss of part of 3p
description of papillary carcinoma
10-15% of renal cell cancer
distal convoluted tubule origin
most common subtype found in dialysis patients
histo appearance of papillary carcinoma
papillary growth (tubular formations with blood vessels in the middle) cells with pink cytoplasm interstitial foam cells (macrophages)
genetics associated with papillary carcinoma
familial and sporadic
associated with trisomy of 7 and 17 and loss of Y
chromosome 7: MET locus (proto-oncogene) mediates cell growth, invasion
description of chromophobe renal cell carcinoma
5% of renal cell cancer
intercalated cell of collecting duct origin
excellent prognosis
histo appearance of chromophobe renal cell carcinoma
cells with prominent cell membranes and pale cytoplasm “vegetable cells”
halo around nucleus