B5.048 - GI Pharmacology

Question 1

most common secretory disorders

Answer 1

acid peptic disease and GERD

Question 2

lifetime prevalence of peptic ulcer disease and GERD

Answer 2

10%

50%

Question 3

drug classes for GERD and peptic ulcer disease

Answer 3

PPIs
H2 antagonists
antacids
mucosal protective agents
antimicrobial agents

Question 4

what are benzimidazoles

Answer 4

PPI

compounds irreversibly inhibit parietal cell proton pump H+K+ATPase

Question 5

activation of PPIs

Answer 5

requires an acidic environment (should be taken with food)

PPIs are unstable at low pH, degradation prevented by enteric coating of tablets

Question 6

how do PPIs retain their efficacy with chronic use

Answer 6

all are prodrugs that are inactive at neutral pH

parietal intracellular canaliculi are upstream from PP target at luminal membrane

Question 7

what are the PPIs

Answer 7

prazole
esomeprazole
omeprazole
lansoprazole
dexlansoprazole
pantoprazole
rabeprazole

Question 8

what are currently the most effective drugs for suppressing gastric acid secretion

Answer 8

PPIs because of gastric response to all stimuli inhibited

Question 9

dosing of PPIs

Answer 9

single daily dose

doest affect pepsin or gastric motility