B5.039 - Prework 2 Patterns of Glomerular Injury COPY

Question 1

Answer 1

entire glomerulus scarred tf up

Question 2

what do focal and diffuse mean

Answer 2

focal - less that half

diffuse - half or more

Question 3

when do you seen thrombosis in glomeruli

Answer 3

as part of thrombotic microangiopathy

also in DIC

Question 4

segmental or global

Answer 4

global

Question 5

segmental or global

Answer 5

segmental

Question 6

Answer 6

tubular pattern

thumbprint deposit

seen in lupus

Question 7

Answer 7

scar in glomerulus in bowmans space

Question 8

types of extrisic hypercellularity

Answer 8

extracapillary, crescents

Question 9

Answer 9

nodular mesangial expansion

seen in DM

Question 10

Answer 10

endocapillary intrinsic hypercellularity

the cells are encroaching upon capillary lumina

hard to find open capillary lumina

Question 11

Answer 11

GBM linear pattern think goodpastures

diffuse

Question 12

types of intrinsic hypercellularity

Answer 12

mesangial, endocapillary, lobular

Question 13

causes of TMA

Answer 13

SLE, HUS/TTP, PSS, HTN

Question 14

Answer 14

segmental sclerosis

Question 15

Answer 15

fibrillar desposits

seen in amyloid

Question 16

Answer 16

mesangial pattern glomerular injury

Question 17

Answer 17

capillary pattern (granular) glomerular injury

Question 18

describe a normal mesangium

Answer 18

1-3 cells per contiguous area; small amount of matrix

Question 19

Answer 19

tuft necrosis

nuclear debris, karyorexis

Question 20

how do you describe a single glomerulus

Answer 20

segmental or global

Question 21

Answer 21

mesangial intrinsic hypercellularity

patent capillary lumina but misangeal matrix abnormal

Question 22

insudate

Answer 22

when fluid passes thru capillary or epithelial cell and causes glassy appearance

Question 23

subtypes of hypercellularity

Answer 23

intrinsic - within glomerular tuft

extrinsic - in glomerulus but outside glomerular tuft

Question 24

tuft necrosis is associated with what

Answer 24

immune mediated injury

Question 25

describe a normal capillary in the glomerulus

Answer 25

patent lumina, smooth GBM contours, small endothelial cells, inconspicuous podocytes

Question 26

Answer 26

Fibrin thrombus

TMA

Question 27

what do segmental or global mean

Answer 27

segmental - portions of glomerulus affected

global - entire glomerulus affected

Question 28

Answer 28

mesangial matrix expansion

glue that holds everything together shows tons of matrix

Question 29

double contours typically due to what

Answer 29

endothelial/subendothelial injury

endothelial cells make new BM, so do podocytes if they need to

can be accompanied by mesangial cell migration (interpositioning) or immune cell infiltration

Question 30

Answer 30

scar with associated insudate (note glassy/hyaline apperance of cells at bottom)

Question 31

intrinsic HC often associated with what

Answer 31

immune complex deposition

Question 32

extrinsic HC often associated with what

Answer 32

GBM break/rupture

goodpasture, ANCA vasculitis…

Question 33

Answer 33

normal glomerulus

Question 34

what are arrows pointing to

Answer 34

granular deposits

Question 35

how do you describe all glomeruli

Answer 35

focal or diffuse

Question 36

causes of MME

Answer 36

DM, HTN

immunoglobulin or immune complex deposition

Question 37

Answer 37

crescent extrinsic hypercellularity

Question 38

Answer 38

crescent extrinsic hypercellularity

silver stain highlights BM

Question 39

Answer 39

double contour BM

“tram tracking” extra BM laid down due to injury