B4.005 - Prework 1 Adrenergic Drugs Podcast Flashcards
What are the types of adrenoreceptors
Alpha1,2
Beta 1, 2
what do Alpha 1 adrenoreceptors do and where are they found
Found in peripheral vasculature
Contract smooth muscle, increase BP
What do alpha 2 adrenoreceptors
presynaptic autoregulation of neurotransmitter release
what do beta 1 receptors have affinity for
apporximately equal affinity for Epi and NE
what do Beta 2 receptors have affinity for
higher for Epi than NE
Receptor responsiveness is regulated by what
activity
what is desensitization of adrenoreceptors and what can cause it
when it stops working because its so consistently activated
what is denervation supersensitivity
when the receptors have upregulated expression and heightened coupling of downstream pathways, usually due to removal of an antagonist
what does epinephrine do
very potent vasoconstrictor, cardiac stimulant
what effects does epinephrine have on the heart specifically and what receptor does it interact with
Beta2
+ inotropic and chronotropic
what effect does epinephrine have on beta 2 receptors
SM relaxation
what does norepinephrine do
more effective on beta 1 almost not at all on beta 2
compensatory vagal reflexes overcome direct positive chronotrophy
what does isoproterenol do
potent non selective beta receptor agonist
+ chronotropic and inotropic actions
Decreases DAP and MAP
what doe dobutamine do
relatively beta 1 selective synthetic catecholamine, also activates alpha 1 receptors
