B3.021 Hypersensitivity

Question 1

what parts of a history are most important in diagnosing immediate HS

Answer 1

symptoms, timing, reproducibility
treatment and outcome
concurrent exercise/meds/etoh

Question 2

what are all the components of diagnosing immediate HS

Answer 2

history
diet details/symptom diary
physical exam
skin prick tests
intradermals

Question 3

how is a skin prick test done

Answer 3

fresh foods used when available
histamine (pos control) - antihistamines in system already
saline (neg control) - hyper reactivity

Question 4

define intolerance

Answer 4

your body cannot break down the food

small amounts -ok

Question 5

define an allergy

Answer 5

your body mistakes the food for something harmful leading to an IgE-mediated reaction
immune response- localized or systemic
can be triggered by eating microscopic amounts

Question 6

define sensitization

Answer 6

may not proceed to clinical disease

proven by IgE immunocap testing, skin testing, or oral challenge

Question 7

how can you “outgrow” allergies

Answer 7

IgE production can die off if you don’t have repeat exposures

Question 8

key cells of anaphylaxis

Answer 8

mast cells

basophils

Question 9

mediators of anaphylaxis

Answer 9

histamine
tryptase
carboxypeptidase A
chymase
PAF
prostaglandins
leukotrienes
other

Question 10

target organs of anaphylaxis

Answer 10

skin
resp
GI
CVS
CNS

Question 11

patch testing

Answer 11

test the possibility that a lesion was due to an allergic contact dermatitis