B2: Organisation Flashcards

1
Q

What is a cell, a tissue, an organ and an organ system?

A

+ Cell: The smallest unit of a living organism
+ Tissue: A group of cells with a similar function & structure
+ Organ: A group of tissues that work together to perform a function
+ Organ System: A series of organs that work together to perform a function

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2
Q

In what order do the Organs of the digestive system connect (from food intake)?

A

Mouth → Oesophagus → Stomach → Small Intestine → Large Intestine → Anus → Rectum

Other Organs that food doesn’t pass through:
Salivary Glands, Liver, Gall bladder, Pancreas

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3
Q

What are the functions of each of the organs in the digestive system?

A

+ Mouth: To break up food
+ Salivary Glands: To produce Amylase & other digestive enzymes
+ Oesophagus: To push food down to the stomach
+ Liver: To produce Bile & filter blood (among other things)
+ Gall Bladder: To store Bile
+ Stomach: To churn & digest food with acid
+ Pancreas: To produce digestive enzymes
+ Small intestine: To digest food & absorb soluble food molecules, like nutrients
+ Large Intestine: To absorb water & produce faeces
+ Rectum: To store faeces until excretion
+ Anus: To excrete faeces

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4
Q

What are Enzymes?

A

Enzymes are Proteins that act as biological catalysts within the body, reducing activation energies for metabolic reactions.

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5
Q

What is the ‘Lock & Key’ Theory?

A

The Lock and key theory is a way of explaining enzyme activity, and it dictates that every enzyme has an active site that matches perfectly in shape to a specific substrate.

Like a lock for a key, each enzyme can only interact with the one substrate whose reaction it is designed to catalyse.

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6
Q

What are the three Main Enzymes for digestion, what do they do, where are they produced and where do they Act?

A
\+ Amylase
> Breaks Carbohydrates down into simple sugars
> Produced by the salivary glands & Pancreas
> Used in the mouth & small intestine
\+ Protease
> Breaks proteins down into amino acids
> Produced by the stomach & pancreas
> Used in the stomach & small intestine
\+ Lipase
> Breaks lipids down into glycerol & fatty acids
> Produced by the pancreas
> Used in the small intestine
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7
Q

What are the two factors that primarily affect enzyme Activity, and in what way do they affect it?

A

+ Temperature
> The Higher the temperature of the environment, the more efficiently the enzyme works, to an extent…
> Above a certain temperature, enzymes begin to denature, and the shape of their active sites deform. This means they can no longer catalyse the reaction of their relevant substrate
> The temperature that enzymes work best in before they denature is known as the optimum temperature
+ pH
> Each Enzyme has an optimum pH level that it works best at.
> For example, enzymes that work in the stomach function best at a lower, more acidic, pH
> Outside of their optimum conditions, these enzymes work less effectively, and in extreme pH conditions, they denature

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8
Q

What are the two functions of Bile and where is it produced and stored?

A

The two functions of Bile:
+ The neutralisation of Stomach Acid
+ The emulsification of lipids
> This increases the surface area of the lipid by turning it into droplets, which allows more Lipase to catalyse its breakdown

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9
Q

Why do we digest food?

A

+ We digest food to break down large, insoluble food molecules into smaller, soluble food molecules that can be absorbed into the bloodstream via diffusion into the villi
+ These smaller food molecules are used to create new lipids, proteins, carbohydrates
+ Some of the absorbed glucose is also used for respiration

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10
Q

How do we test foods for Proteins, Starch & Sugars?

A

+ To test for the presence of proteins, use Biuret solution
> If the sample turns purple, protein is present
+ To test for the presence of sugars
> Heat for two minutes, and depending on the concentration of sugar, the solution will turn green, yellow or red
+ To test for the presence of starch, use iodine
> If the sample turns black/blue, starch is present
+ To test for the presence of lipids, use Sudan III or Ethanol
> If a red layer gathers at the top using Sudan III, lipids are present
> If, when shaken with ethanol, the food solution turns cloudy, lipids are present

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11
Q

What are the four main Chambers of the Heart, and how do they work to pump blood?

A

The four chambers of the heart are arranged in the following arrangement
Right Atrium Left Atrium
Right Ventricle Left Ventricle

+ The atriums fill with blood from the vena cava & pulmonary vein
> The heart pumps the muscles, forcing blood from the atriums into the ventricles
> The blood then pumps again, sending blood in the ventricles to the lungs and around the body through the pulmonary artery & aorta respectively

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12
Q

What are the five main blood Vessels of the Heart, and what do they do?

A

+ De-oxygenated blood from the rest of the body enters the right atrium through the VENA CAVA
+ This blood is pumped into the right ventricle, and then pumped out into the PULMONARY ARTERY, which leads to the lungs
+ At the lungs, the blood is oxygenated and returned to the heart via the PULMONARY VEIN, which connects to the left atrium
+ The oxygenated blood is pumped from the left atrium into the left ventricle, and is then pumped through to the rest of the body via the AORTA
+ There are also CORONARY ARTERIES that supply oxygenated blood to the heart

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13
Q

How is your heartbeat regulated?

A

+ The heartbeat is regulated by a group of cells known as the pacemaker, and these regulate your normal resting heart rate
> Electrical, artificial pacemakers can be used to regulate the heart rate in the event of irregularities

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14
Q

Why is the cardiovascular system a double circulatory system?

A

The cardiovascular system is a double circulatory system because for every circuit of the system, blood passes through the heart twice

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15
Q

How are the lungs structured?

A

+ The Trachea (or windpipe) splits into two tubes called bronchi, which then split into smaller tubes called bronchioles before finally ending with tiny air sacs called alveoli
+ There are millions of alveoli in the lungs

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16
Q

How are the lungs adapted to their function?

A

+ Constant Breathing maintains the steep concentration gradient of Carbon dioxide & Oxygen
+ Constant blood flow in the capillaries of the alveoli maintains the steep concentration gradient of oxygen & carbon dioxide
+ The distance between the capillaries and alveoli’s ‘air sac’ is only one cell thick, to minimise the distance of diffusion

17
Q

What are the three Blood Vessels, and how are they adapted to their functions?

A

+ Arteries: Carry blood away from the heart. This blood is pumped at a high pressure, so…
> The vessels have thick walls to withstand the pressure
> The vessels are made of elastic fibres to withstand the pressure
> The vessels have a small lumen (cross section)
+ Veins: Carry blood from the body towards the heart. This blood is under less intense pressure, so…
> They have thin walls
> Have large lumens to facilitate an equal quantity of blood (since it is flowing at a slower pace)
> Have valves to prevent backflow
+ Capillaries: Carries blood to individual cells. This blood is under extremely low pressure, so…
> They’re only one cell thick

18
Q

What is blood composed of?

A

+ Blood is composed of three things suspended in plasma, a fluid containing CO2, transports cells, hormones, waste etc. These are the following…
> Platelets, which work to help wounds clot
> Red blood cells, which contain haemoglobin (a substance capable of binding to oxygen), carry oxygen to cells
> White blood cells, which help fight pathogens & disease

19
Q

How are Platelets, White blood cells & red blood cells adapted to their functions?

A

+ Red Blood Cells:
> Have no nucleus, to store more haemoglobin
> Have a biconcave shape for increased surface area, to increase the diffusion rate of oxygen
> Are small, so they can fit into capillaries
+ White blood cells
> Can change shape, to engulf pathogens and enter other cells
> Have a nucleus
+ Platelets
> Are fragments of cells, which gather in large numbers to clot wounds
> Do not have a nucleus

20
Q

What is Cardiovascular Heart Disease (CHD)?

A

Cardiovascular heart disease is the buildup of fatty deposits in the coronary arteries, narrowing them, causing a reduced blood flow and reduced supply of oxygen to the heart. (This buildup is known as Atherosclerosis)

21
Q

What are the two ways that CHD can be treated?

A

CHD can be treated in two ways…
+ Using Stents: Stents are small metal wire grids that are surgically implanted into the coronary arteries and expanded, causing the fatty deposits to be pushed back and the artery widened.
> Pros: Keep you alive
: Cons: Require surgery, cause build up of scar tissue, require blood clot preventing drugs
+ Using Statins: Statins are drugs that reduce the amount of harmful cholesterol, limit the liver’s production of cholesterol and reduce the rate it is deposited. This helps prevent the development or worsening of heart disease.
> Pros: Cheap & do not require surgery
> Cons: May have side effects & people may forget to take them

22
Q

What are the two ways Blood Valves can be faulty?

A

+ Leaky Valves: Valves cannot close properly, and backflow in veins occur
+ Stiff/stuck valves: Valves do not open fully, or require more effort to open
> Both of these conditions mean more effort is required to circulate blood
> This places stress on the heart (Symptoms of this can be shortness of breath, swelling in the feet & ankles as well as unusual tiredness)
+ Faulty valves can be replaced with animal or artificial replacements

23
Q

Cardiovascular Disease can lead to Heart failure. What are the two ways heart failure can be treated?

A

+ Donor Hearts: A heart transplanted from someone else
> Pros: Won’t wear down, function like the replaced organ
> Cons: Requires a suitable donor, the organ will be rejected if immunosuppressants are not taken, making the patient more susceptible to infections
+ Artificial Hearts: Machinery used to keep people with poor hearts alive while a donor is not available, or if their heart needs to rest & recover
> Pros: Can be used when a donor is not available
> Cons: Short term (eventually wears out), requires an electrical supply

24
Q

How do some diseases interact to provoke illness?

A

+ Immune system defects mean some are more susceptible to disease (HIV)
+ Viruses in cells can trigger cancers to form
+ Immune reactions to pathogens can cause allergic reactions (i.e. rashes, asthma)
+ Severe illness can lead to other mental illnesses like depression

25
Q

What are the human costs of Non-communicable diseases?

A

+ Poorer quality of life
+ Shorter lifespan
+ Families of sufferers have caring responsibilities

26
Q

What are the financial costs of non-communicable diseases?

A

+ Healthcare Cost
+ Disease research cost
+ Awareness Campaigns

+ Reduced income due to illness
+ Personal care costs
+ Home adjustment costs
+ Specialist equipment costs

27
Q

How can risk factors for non-communicable diseases be categorised?

A

+ Lifestyle (e.g. Stress, exercise, UV exposure, Radiation exposure)
+ Substances (e.g. Diet, smoking, alcohol, pollution)

28
Q

What risk factors can increase the likelihood of cardiovascular heart disease?

A

+ A diet high in saturated fats
+ Smoking: weakens artery lining, reduces oxygen levels and causes increased heart rate
+ Lack of exercise

29
Q

What are other risk factors can lead to certain diseases?

A

+ Obesity (more fat surrounding the abdomen)
> Can lead to Type 2 diabetes, where cells become resistant to insulin
+ Excessive Alcohol Intake
> Can lead to Liver disease, where the liver becomes too fatty
> Can also lead to brain function damage, where nerve cells are damaged
+ Smoking
> Can lead to lung disease, where it becomes difficult to move air into and out of the lungs, whether due to bronchial inflammation or alveoli break down
> Can lead to lung cancer, as cigarettes contain many carcinogenic chemicals

30
Q

What are effects of some risk factors on unborn babies?

A

+ Smoking while pregnant increases the risk of…
> Miscarriage, premature birth & SIDS
+ Alcohol consumption during the first 3 months of pregnancy can lead to…
> Miscarriage & premature birth
+ Heavy drinking during pregnancy can lead to foetal alcohol syndrome [FAS], which causes…
> poor growth, facial abnormalities & learning difficulties

31
Q

What are some risk factors that lead to cancer?

A

+ Carcinogens are substances or radiation forms that can cause cancer. The following risk factors are, or contain, carcinogens…
> Tobacco
> Alcohol
> Occupational Carcinogens (found in the workplace)
> ionising radiation (Can change atoms in DNA & cause mutations) [e.g. UV radiation]
+ Other factors that can lead to cancer are…
> Obesity
> Genetics

32
Q

What are cancerous cells, and what are tumours?

A

+ Cancerous cells are cells that divide uncontrollably, causing rapid growth
+ This rapid, uncontrolled growth of cells can lead to clusters of cells called tumours. These tumours can be benign or malignant.

33
Q

What is the difference between a benign & malignant tumour?

A

+ A Benign Tumour
> Has abnormal cell growth
> Is contained in one area, usually surrounded by a membrane
> Does not invade other parts of the body
+ A Malignant Tumour
> Has abnormal cell growth
> Is cancerous and spreads to other parts of the body, forming secondary tumours and invading neighbouring tissues
> Can be caused by lifestyle and/or genes

34
Q

How are Xylem Vessels, Phloem Vessels & Root hair cells adapted to their function?

A

+ Xylem Vessels
> Dead & hollow, to prevent obstruction to transpiration
> Strengthened with a substance called lignin
+ Phloem Vessels
> Have small holes in the end of each cell to allow cell sap to move through them
+ Root Hair cells
> Take up water via osmosis
> Take up minerals via Active Transport
> Have lots of mitochondria for Active Transport

35
Q

What are some of the tissues found in plants?

A

+ Epidermal tissue: Covers the top of the plant in a waxy, waterproof coating
+ Palisade Mesophyll: Contains many chloroplasts and traps sunlight for use in photosynthesis
+ Spongy Mesophyll: Contains large air spaces for the movement of oxygen and carbon dioxide [Note: Photosynthesis also occurs here]
+ Xylem & Phloem Vessels: Transport Water/Minerals and Glucose around the plant respectively
+ Meristem Tissue: undifferentiated tissue found at the tips of shoots & roots

36
Q

How do stomata work to regulate water loss & gas exchange?

A

+ Stomata, small gaps in the underside of a leaf, have guard cells on either side of them, which open and close the gap.
> When water is in abundance, the guard cells swell with water and the stomata open to allow gas exchange of carbon dioxide and oxygen into the leaf for photosynthesis. This occurs because the plant can afford to lose water.
> When water is not in abundance, the guard cells lose water and go flacid, causing the stomata to close so that water loss can be minimised.

37
Q

What is Transpiration, and what are the factors that affect transpiration?

A

+ Transpiration is the movement of Minerals and water through Xylem vessels from the roots of the plants to its leaves.
> It occurs only in one direction
+ The rate of transpiration will increase if…
> The humidity is low
> The temperature is high
> The air flow is high
> The light intensity is high

38
Q

What is Translocation?

A

Translocation is the bidirectional movement of glucose through Phloem vessels to areas of the plant which are respiring or to storage organs